Evidence map›Paper›PMID 41496729›Full record

ReviewTransactions of the Royal Society of Tropical Medicine and Hygiene2026

Schistosoma japonicum infection: clinical significance of ultrasound findings.

Joachim Richter, Hannah Wei Wu, An Ning, Mario A Jiz, Ralph Aniceto, Jennifer Friedman, Andreas Neumayr, Christoph Hatz

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Transactions of the Royal Society of Tropical Medicine and Hygiene, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Joachim RichterInstitute of International Health, Global Health Centre of Charité, Charité University Medicine, D 13353 Berlin, Germany.ORCID 0000-0002-1930-2944
Hannah Wei WuCenter for International Health Research, Rhode Island Hospital, Providence, RI 02903, USA.
An NingJiangxi Institute of Parasitic Diseases Prevention and Treatment, Nanchang 330096 Jiangxi, China.
Mario A JizDepartment of Immunology, Research Institute of Tropical Medicine, Filinvest Corporate City Alabang, Muntinlupa City 1781  Philippines.
Ralph AnicetoDepartment of Immunology, Research Institute of Tropical Medicine, Filinvest Corporate City Alabang, Muntinlupa City 1781  Philippines.
Jennifer FriedmanCenter for International Health Research, Rhode Island Hospital, Providence, RI 02903, USA.
Andreas NeumayrSwiss Tropical and Public Health Institute 4123 Allschwil, Switzerland.
Christoph HatzSwiss Tropical and Public Health Institute 4123 Allschwil, Switzerland.

Funding

Biomarkers to Identify Individuals at RIsk for Progression of S. Japonicum Associated Hepatic Fibrosis with Point of Care Test DevelopmentU01AI168560 · NIAID · RHODE ISLAND HOSPITAL · PI JENNIFER F FRIEDMAN, Mario Antonio II Larida Jiz · 2022 to 2026
$2.5M
NIAID NIH HHS U01 AI168560
6 · The paper itself

Abstract

Schistosoma japonicum infection can cause severe hepatic complications associated with portal hypertension, which may lead to death by bleeding from esophageal varices. Ultrasonography (US) enables the identification of two different types of liver fibrosis characteristic for S. japonicum infection: interseptal fibrosis (ISF) and portal fibrosis (PF). To date, these two forms of liver fibrosis have not been sufficiently investigated with regard to their potential to cause portal hypertension. Among the 121 reports published, only 56 (46.3%) distinguish between ISF and PF. In 31/56 (55.4%) of these publications, patients with only ISF, two (3.6%) with only PF, as well as 23 (41.1%) with concomitant ISF and PF, are reported. US signs of portal hypertension are reported in 10/25 (40.0%) of publications reporting PF, of which 2/2 (100%) of publications report PF alone and 8/23 (34.8%) of publications report concurrent PF and ISF. Also, 2/31 (6.5%) of publications report that ISF alone is associated with portal hypertension. Thus, PF appears to be the main risk factor for portal hypertension. Future studies need to assess the exact nature of liver fibrosis caused by S. japonicum in a standardized way to clarify the individual contributions of PF and ISF to morbidity.

Indexed as

Hypertension, PortalLiver CirrhosisSchistosoma japonicumSchistosomiasis japonicaAnimalsEsophageal and Gastric VaricesHumansLiverRisk FactorsUltrasonographyhepatosplenic schistosomiasis ultrasonographyintestinal schistosomiasisportal hypertensionSchistosoma japonicum

Identifiers

PMID41496729
PMCPMC12925349

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.