ArticleImmunoTargets and therapy2025
Flow Cytometric Profiling of Peripheral Immune Checkpoints Predicts Prognosis and Reveals PD-1/Treg/IL-10 Crosstalk in B-Cell Lymphoma.
Article in ImmunoTargets and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Minimal residual disease in diffuse large B-cell lymphoma after first-line therapy: Defining the continuum from metabolic remission to molecular clearance.British journal of haematology · 2026Review
- Integrating Flow Cytometry in the Diagnostic Work of HIV-Associated Hodgkin's Lymphomas.Journal of cellular and molecular medicine · 2026Review
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Authors and funding
6 authors.
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Abstract
Background: The clinical significance and mechanistic role of immune checkpoints (ICs) in B-cell lymphoma remain underexplored. This study investigates peripheral IC expression as prognostic biomarkers and their interaction with Tregs and IL-10. Methods: Peripheral blood from 140 B-cell lymphoma patients was analyzed using flow cytometry (PD-1, CTLA-4, LAG-3, TIM-3 on CD4 Results: Aggressive lymphomas and cases with multiple extranodal sites showed significantly elevated IC expression (all p < 0.05). R/P patients demonstrated markedly higher PD-1 expression (CD4 Conclusion: Peripheral T-cell ICs, particularly PD-1 and CTLA-4, are significant prognostic biomarkers in B-cell lymphoma. The correlation between PD-1
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