RNA binding protein HuD regulates the biosynthesis of glucagon-like peptide 1 in intestinal L-cells.

Sukyoung Han, Myeongwoo Jung, Seungyeon Ryu, Seongho Cha, Hyosun Tak, Seung Min Jeong, Eun Kyung Lee

Abstract read

In one paragraph

Article in Biochemistry and biophysics reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Sukyoung HanDepartment of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul, 06591, South Korea.

Myeongwoo JungDepartment of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul, 06591, South Korea.

Seungyeon RyuDepartment of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul, 06591, South Korea.

Seongho ChaDepartment of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul, 06591, South Korea.

Hyosun TakCancer Research Center of Lyon (CRCL), UMR INSERM U1052 / CNRS 5286, Lyon, France.

Seung Min JeongDepartment of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul, 06591, South Korea.

Eun Kyung LeeDepartment of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul, 06591, South Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated HuD (ELAVL4), a neuronal RNA-binding protein with emerging endocrine functions, as a regulator of GLP-1 biogenesis in intestinal L-cells. Using absolute qPCR and immunofluorescence, we found that HuD was significantly expressed in the GLUTag cells derived from mice intestinal L-cell line and was co-localized with GLP-1-positive cells in the small intestine of mice. RNA interference-mediated HuD knockdown reduced both GLP-1 immunoreactivity and levels. Mechanistically, RNA immunoprecipitation and biotinylated 3'UTR pull-down demonstrated that HuD binds to the mRNAs of the

Indexed as

GLP-1HuDIntestinal L-cellProglucagonProhormone convertase 1/3RNA binding protein

Identifiers

PMID41496908

DOI10.1016/j.bbrep.2025.102415

PMCPMC12767712

What Socratic holds

Textmetadata

LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.