ArticleAnnals of medicine and surgery (2012)2026
Identification of potential genes and candidate drugs for intrahepatic cholestasis of pregnancy based on bioinformatics.
Article in Annals of medicine and surgery (2012), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: The aim of this study is to find potential biomarkers and drugs in intrahepatic cholestasis of pregnancy (ICP) by combining bioinformatics and experimental validation strategies. Method: Differentially expressed genes were obtained by analyzing the GSE282182 GEO dataset, after which the weighted gene co-expression network analysis was performed. The intersection of these two analyses yielded core genes. The MCODE module was used to analyze and identify key genes for further study, including gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) and immune infiltration analysis. Potential target drugs for the above target genes were obtained from the Comparative Toxicogenomics Database. Finally, external database validation and cell experiment validation were performed. Results: A total of 10 core genes ( Conclusion: This study identified 10 core genes, and the relationship between
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