Evidence map›Paper›PMID 41497174›Full record

ArticleChemical science2026

Single-cell structural lipidomics using a miniature dual-LIT mass spectrometer.

Zhijun Cai, Ningxi Li, Simin Cheng, Zheng Ouyang, Xiaoxiao Ma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhijun CaiState Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instruments, Tsinghua University Beijing 100084 China ouyang@mail.tsinghua.edu.cn maxx@mail.tsinghua.edu.cn.
Ningxi LiState Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instruments, Tsinghua University Beijing 100084 China ouyang@mail.tsinghua.edu.cn maxx@mail.tsinghua.edu.cn.
Simin ChengState Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instruments, Tsinghua University Beijing 100084 China ouyang@mail.tsinghua.edu.cn maxx@mail.tsinghua.edu.cn.
Zheng OuyangState Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instruments, Tsinghua University Beijing 100084 China ouyang@mail.tsinghua.edu.cn maxx@mail.tsinghua.edu.cn.
Xiaoxiao MaState Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instruments, Tsinghua University Beijing 100084 China ouyang@mail.tsinghua.edu.cn maxx@mail.tsinghua.edu.cn.ORCID https://orcid.org/0000-0003-1205-6485

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Structural lipidomics provides comprehensive information on lipidomes, and there is great interest in applying it to single-cell analysis for accurate cell phenotyping and lipid pathway studies. However, structural lipidomics relies on tandem mass spectrometry analysis of a large number of lipid species, which remains challenging for single-cell analysis due to the small sample amounts. Herein, using a miniature dual-linear ion trap (LIT) mass spectrometer with enhanced ion processing capability, we developed an effective strategy to achieve annotations of more than 100 lipid species in a single cell with high structural specificity. The ion utilization efficiency was greatly improved with multi-stage MS

Identifiers

PMID41497174
PMCPMC12766753

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.