ArticleJournal of exercise rehabilitation2025
Comparative study of treadmill and swimming exercises on spinal regeneration and reactive astrocytes in the brain after spinal cord injury.
Article in Journal of exercise rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Combined effects of treadmill exercise and naringenin treatment on neuronal survival and corticospinal tract fibers sprouting after spinal cord injury.Journal of exercise rehabilitation · 2026Article
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Authors and funding
3 authors.
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Abstract
The purpose of this study is to compare the effects of treadmill and swimming exercise on cell survival and reactive astrogliosis in the spinal cord and brain after spinal cord injury (SCI). Thirty-two male rats were randomly assigned to four groups: the normal group (Norm, n=8), the SCI+sedentary group (Seden, n=8), the SCI+treadmill exercise group (Tread, n=8), and the SCI+swimming exercise group (Swim, n=8). All rats in the SCI groups were allowed to recover for 2 weeks after injury, and then underwent 4 weeks of low-intensity treadmill and swimming exercise. In the spinal cord, both exercise interventions decreased the cavity formation around the injury, and significantly increased induction levels of growth associated protein-43, with greater improvements in the Tread group. In the motor cortex and hippocampus of the brain, the Tread group upregulated B-cell leukemia/lymphoma 2 and downregulated cleaved-caspase-3 and glial fibrillary acidic protein relative to the Seden group, indicating enhanced cell survival and reduced reactive astrogliosis in the injury site. Compared with swimming, treadmill exercise further improved tissue preservation and neural circuit-level recovery across the spinal cord, motor cortex, and hippocampus after SCI. Thus, our findings suggested evidence that treadmill exercise might be one of the rehabilitation strategies to support the spinal cord and brain after SCI.
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