ArticleAddiction neuroscience2025
Recruitment of specific dopamine neuron sub-circuits by opioids.
Article in Addiction neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- Mesolimbic and mesocortical pathways differentially support fentanyl-context associations.Psychopharmacology · 2026Article
- Can the incentive-sensitization theory of addiction incorporate addiction to opioid drugs?Psychopharmacology · 2026Review
- Sensor sensibility: Divergent measurements of dopaminergic signaling to acute morphine administration via fiber photometry.bioRxiv : the preprint server for biology · 2026Article
- Methamphetamine-Fentanyl Polysubstance Administration Produces Social Deficits and Corticolimbic Stress-Reward Circuit Adaptations.Research square · 2026Article
- Mu-opioid and nociceptin receptors show divergent, cell-type-specific actions in the mesocorticolimbic reward system in opioid use disorder.Frontiers in cellular neuroscience · 2026Review
- Projection-defined ventral tegmental area neurons exhibit fentanyl-induced molecular and functional adaptations that differentially support drug-context associations.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Opioids have strong addictive and rewarding effects, largely attributed to their interaction with the dopamine (DA) system. Within the ventral tegmental area (VTA), opioids increase DA neural activity by disinhibiting-or decreasing the tonic inhibition of-DA neurons. This disinhibition results in an increase in DA in the nucleus accumbens, which has been widely implicated in addiction. With recent developments suggesting rich VTA DA neuron heterogeneity, a key question is whether opioid exposure activates distinct DA neuron subsets. Here, we address (i) whether this activation is uniformly distributed across the midbrain or, alternatively, is enriched in specific anatomically restricted DA populations, and (ii) the specificity of projections of activated DA neurons, giving insight into the circuitry receiving DA following opioid administration. Using intersectional cFos-based labeling, we find that captured cells are biased towards the VTA over the substantia nigra pars compacta (SNc), specifically towards the
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.