Evidence map›Paper›PMID 41497488›Full record

ArticleJournal of diabetes research2025

Elevated Uric Acid/Albumin Ratio Predicts Poor Coronary Collateral Circulation in Type 2 Diabetic Patients With Stable Coronary Artery Disease.

Lin Shuang Mao, Yi Xuan Wang, Yang Qi, Zhi Ran Yue, Feng Hua Ding, Xiao Qun Wang, Lin Lu, Wei Feng Shen, Ying Shen

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06054126 (The Development of Coronary Collateralization in Type 2 Diabetic Patients With Chronic Total Occlusion), which is not on this map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06054126 unknown statusnot on this map

The Development of Coronary Collateralization in Type 2 Diabetic Patients With Chronic Total Occlusion

TypeobservationalSponsorRuijin HospitalRan2010 to 2026Enrolled2,000ConditionsChronic Total Occlusion of Coronary Artery, Diabetes Mellitus, Type 2ArmsEchocardiography
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lin Shuang MaoDepartment of Cardiovascular Medicine, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, shsmu.edu.cn.ORCID https://orcid.org/0000-0002-0891-8380
Yi Xuan WangDepartment of Cardiovascular Medicine, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, shsmu.edu.cn.ORCID https://orcid.org/0009-0009-0633-9885
Yang QiDepartment of Cardiovascular Medicine, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, shsmu.edu.cn.ORCID https://orcid.org/0009-0004-4702-5640
Zhi Ran YueDepartment of Cardiovascular Medicine, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, shsmu.edu.cn.ORCID https://orcid.org/0009-0002-6672-301X
Feng Hua DingDepartment of Cardiovascular Medicine, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, shsmu.edu.cn.ORCID https://orcid.org/0000-0001-9507-4704
Xiao Qun WangDepartment of Cardiovascular Medicine, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, shsmu.edu.cn.ORCID https://orcid.org/0000-0003-0956-8041
Lin LuDepartment of Cardiovascular Medicine, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, shsmu.edu.cn.ORCID https://orcid.org/0000-0003-0145-8008
Wei Feng ShenDepartment of Cardiovascular Medicine, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, shsmu.edu.cn.ORCID https://orcid.org/0000-0002-7093-2001
Ying ShenDepartment of Cardiovascular Medicine, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, shsmu.edu.cn.ORCID https://orcid.org/0009-0005-4179-0955

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The uric acid/albumin ratio (UAR) has been shown to correlate with coronary disease severity and clinical outcome. This study investigated the predictive value of UAR on coronary collateralization (CC) in patients with type 2 diabetes mellitus (T2DM) and stable coronary artery disease. Methods: Serum levels of uric acid and albumin were determined and UAR was calculated in 1558 T2DM patients with chronic total occlusion of at least one major coronary artery. The degree of collaterals supplying to the distal occluded bed from the contra-lateral vessel was graded by Rentrop scoring system. Results: Serum uric acid decreased and albumin increased gradually across Rentrop score 0 to 3, resulting in a higher UAR in patients with poor collaterals (Rentrop score 0 or 1) compared to those with good collaterals (Rentrop score 2 or 3) (9.74 [8.53-11.95] vs. 7.74 [6.61-8.84], Conclusions: Elevated UAR predicts poor coronary collateral circulation in T2DM patients with stable coronary disease especially when renal function is preserved. These findings may help physicians better identify high-risk patients and guide individualized management strategies. Trial Registration: ClinicalTrials.gov identifier: NCT06054126.

Indexed as

Collateral CirculationCoronary Artery DiseaseCoronary CirculationDiabetes Mellitus, Type 2Serum AlbuminUric AcidAgedBiomarkersFemaleHumansMaleMiddle AgedPredictive Value of TestsBiomarkersSerum AlbuminUric Acidchronic total occlusioncoronary collateralizationstable coronary artery diseasetype 2 diabetesuric/albumin ratio

Identifiers

PMID41497488
PMCPMC12767224

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.