Evidence map›Paper›PMID 41497495›Full record

ReviewSynthetic and systems biotechnology2025

Development and application of synthetic biology tools for improved production of human breast milk components.

Manxiang Zhu, Xianhao Xu, Xinyu Bi, Shixiu Cui, Yanfeng Liu, Guocheng Du, Xueqin Lv, Long Liu, Jianghua Li

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Synthetic and systems biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Manxiang ZhuKey Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, Wuxi, 214122, China.
Xianhao XuKey Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, Wuxi, 214122, China.
Xinyu BiKey Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, Wuxi, 214122, China.
Shixiu CuiJiaxing Institute of Food Biotechnology, Jiaxing, 314000, China.
Yanfeng LiuKey Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, Wuxi, 214122, China.
Guocheng DuKey Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, Wuxi, 214122, China.
Xueqin LvKey Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, Wuxi, 214122, China.
Long LiuKey Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, Wuxi, 214122, China.
Jianghua LiKey Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, Wuxi, 214122, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human breast milk (HBM) is composed of various components that are crucial for providing essential nutrients and enhancing infant immune system. Recently, the synthesis of HBM components through microbial fermentation has garnered significant attention due to its potential to reduce production costs, simplify manufacturing processes, and mitigate environmental pollution. However, this approach results in low yield and is difficult to scale up at the industrial level. Therefore, various synthetic biology tools have been used to enhance the efficiency of HBM component synthesis. This review first summarizes several synthetic biology tools that may improve HBM component production. Next, we have summarized HBM component production using microbial cell factories. Finally, we have summarized the challenges and opportunities presented by the construction of cell factories for the synthesis of HBM using synthetic biology tools. This article therefore provides a general guide to the construction of microbial cell factories for HBM components.

Indexed as

Artificial intelligenceGene editing toolsGenetic circuitsHuman milk compositionSynthetic biology

Identifiers

PMID41497495
PMCPMC12767191

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.