Evidence map›Paper›PMID 41497588›Full record

ArticlebioRxiv : the preprint server for biology2025

Astrocyte-derived extracellular vesicles as antigen-specific therapy for neuromyelitis optica spectrum disorder in the mouse model.

Hamed Naziri, Gholamreza Azizi, Bogoljub Ciric, Guang-Xian Zhang, Abdolmohamad Rostami

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hamed NaziriDepartment of Neurology, Thomas Jefferson University, Philadelphia, PA, United States.
Gholamreza AziziDepartment of Neurology, Thomas Jefferson University, Philadelphia, PA, United States.
Bogoljub CiricDepartment of Neurology, Thomas Jefferson University, Philadelphia, PA, United States.
Guang-Xian ZhangDepartment of Neurology, Thomas Jefferson University, Philadelphia, PA, United States.
Abdolmohamad RostamiDepartment of Neurology, Thomas Jefferson University, Philadelphia, PA, United States.

Funding

IL-37: a novel regulator of inflammation in CNS autoimmunityR01AI160189 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI A.M. Rostami · 2021 to 2026
$1.9M
Oligodendrocyte extracellular vesicles: a novel therapy for CNS autoimmunityR01AI152251 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI ROSTAMI, A.M. · 2020 to 2025
$1.9M
NIAID NIH HHS R01 AI152251NIAID NIH HHS R01 AI160189
6 · The paper itself

Abstract

Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disease of the central nervous system (CNS), characterized by Th17 cell responses and serum antibodies against the water channel aquaporin-4 (AQP4) on astrocytes. To avoid systemic immunosuppression by current therapies, an approach is to induce antigen (Ag)-specific tolerance by injecting an AQP4 epitope used to trigger the disease (e.g., AQP4

Indexed as

astrocyteastrocyte-derived extracellular vesicles (AST-EVs)experimental NMOSDIL-10inflammationNeuromyelitis optica spectrum disorder (NMOSD)

Identifiers

PMID41497588
PMCPMC12767533

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.