Evidence map›Paper›PMID 41497656›Full record

ArticlebioRxiv : the preprint server for biology2025

Comprehensive Mapping of the Virus and Host Factors that Guide the Paths of HIV-1 Escape from a Therapeutic.

Aaron N Gillman, Cassian M Birler, Rohith Rao Vujjini, Mohammad Fili, Samuel A McCarthy-Potter, Wilson Chen, Madeline M Broghammer, Guiping Hu, Margaret J Gartland, Manyu Prakash and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Aaron N GillmanDepartment of Microbiology and Immunology, The University of Iowa, Iowa City, IA.
Cassian M BirlerDepartment of Microbiology and Immunology, The University of Iowa, Iowa City, IA.
Rohith Rao VujjiniDepartment of Microbiology and Immunology, The University of Iowa, Iowa City, IA.
Mohammad FiliDepartment of Systems Engineering and Operations Research, George Mason University, Fairfax, VA.
Samuel A McCarthy-PotterDepartment of Microbiology and Immunology, The University of Iowa, Iowa City, IA.
Wilson ChenViiV Healthcare, Research Triangle Park, North Carolina, USA.
Madeline M BroghammerDepartment of Microbiology and Immunology, The University of Iowa, Iowa City, IA.
Guiping HuDepartment of Systems Engineering and Operations Research, George Mason University, Fairfax, VA.
Margaret J GartlandViiV Healthcare, Research Triangle Park, North Carolina, USA.
Manyu PrakashViiV Healthcare, Brentford, United Kingdom.
Annika HelversonDepartment of Biostatistics, School of Public Health, The University of Iowa, Iowa City, IA.
Grant BrownDepartment of Biostatistics, School of Public Health, The University of Iowa, Iowa City, IA.
Hillel HaimDepartment of Microbiology and Immunology, The University of Iowa, Iowa City, IA.ORCID 0000-0002-6071-5089

Funding

Predicting HIV-1 escape from therapeutics in vitro and in vivo - toward personalizing medicine for people living with HIVR01AI170205 · NIAID · UNIVERSITY OF IOWA · PI Hillel Haim · 2023 to 2026
$2.3M
NIAID NIH HHS R01 AI170205
6 · The paper itself

Abstract

HIV-1 resistance to therapeutics can emerge through diverse mutational routes, yet the determinants guiding pathway selection

Indexed as

Antiviral therapeuticsBMS-626529Envelope glycoproteinsFostemsavirHIV-1Selection PressuresVirus escapeVirus EvolutionVirus fitness

Identifiers

PMID41497656
PMCPMC12767509

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.