Evidence map›Paper›PMID 41497681›Full record

ArticleWorld journal of experimental medicine2025

Short-term blood pressure variability as an indicator of the adaptive capacity of patients with chronic heart failure.

Natalia S Akimova, Larisa E Konshina, Anastasiya E Runnova, Maksim O Zhuravlev, Tatyana M Bogdanova, Anton R Kiselev, Yury G Shvarts

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Beyond distance and heart rate: Reading 6-minute walk testWorld journal of experimental medicine · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Natalia S AkimovaDepartment of Faculty Therapy, V.I. Razumovsky Saratov State Medical University, Saratov 410012, Saratovskaya Oblast', Russia.
Larisa E KonshinaDepartment of Faculty Therapy, V.I. Razumovsky Saratov State Medical University, Saratov 410012, Saratovskaya Oblast', Russia.
Anastasiya E RunnovaLaboratory of Open Biosystems and Artificial Intelligence, V.I. Razumovsky Saratov State Medical University, Saratov 410012, Saratovskaya Oblast', Russia.
Maksim O ZhuravlevLaboratory of Open Biosystems and Artificial Intelligence, V.I. Razumovsky Saratov State Medical University, Saratov 410012, Saratovskaya Oblast', Russia.
Tatyana M BogdanovaDepartment of Propaedeutics of Internal Medicine, V.I. Razumovsky Saratov State Medical University, Saratov 410012, Saratovskaya Oblast', Russia.
Anton R KiselevCoordinating Center for Fundamental Research, National Medical Research Center for Therapy and Preventive Medicine, Moscow 101990, Moskva, Russia. antonkis@list.ru.
Yury G ShvartsDepartment of Faculty Therapy, V.I. Razumovsky Saratov State Medical University, Saratov 410012, Saratovskaya Oblast', Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe six-minute walk test (6MWT) allows to determine, in addition to the main parameters, the time of heart rate recovery (THRR), cardiac function, adaptation index (AI), which characterize the compensatory reserve of patients with chronic heart failure (CHF). At the same time, the significance of these parameters in patients taking beta-blockers for CHF is insufficiently studied, taking into account the negative chronotropic effect of drugs. In this regard, it is relevant to identify factors that can characterize the compensatory capabilities of a patient with CHF during 6MWT, not related to the calculation of heart rate.

aimTo identify hemodynamic indicators of the adaptive capabilities of patients with CHF during paired 6MWT depending on their intake of beta-blockers.

methodsSeventy-four patients with compensated CHF due to coronary heart disease and/or hypertension formed the main group, comprising 46 individuals who were taking beta-blockers, and a comparison group comprising 28 individuals who had not been taking beta-blockers for at least one month before 6MWT. All participants underwent Doppler echocardiography (DECG), paired 6MWT, with assessment of hemodynamic parameters before and after both the first and second test. AI, THRR, blood pressure variability (BPV) were calculated. Multivariate, correlation analyses, univariate analysis of variance were used.

resultsThere were no significant associations between adaptation characteristics and DECG parameters or functional class (FC) of CHF in patients of the main group. In the comparison group, the indicators of compensatory reserve were significantly and directly associated with left ventricular ejection fraction (LVEF), and inversely with FC CHF and cardiac cavity size. In both groups, a greater difference in systolic blood pressure between the end of the first and the beginning of the second 6MWT was significantly associated with a higher index of right ventricular systolic dysfunction (Tricuspid annular plane systolic excursion) and LVEF, as well as a smaller left ventricular size and mass, and a lower pulmonary artery systolic pressure in patients in the main group.

conclusionSystolic BPV, measured immediately after 6MWT and 20 minutes after its completion, can indirectly characterize the compensatory reserve in patients with CHF, regardless of their beta-blocker intake.

Indexed as

Adaptive capacityBeta-blockersBlood pressure variabilityChronic heart failureSix-minute walk test

Identifiers

PMID41497681
PMCPMC12767241

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.