Evidence map›Paper›PMID 41497804›Full record

ArticleStem cells international2025

Modeling Thoracic Aortic Dissection Using Patient-Specific iPSCs Reveals VSMC Dysfunction and Extracellular Matrix Dysregulation.

Peifeng Jin, Yubin Xu, Sixian Wang, Lu Ding, Yuhao Chen, Miqi Zhou, Xiufang Chen, Xiaofang Fan, Yongsheng Gong, Ming Li and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Peifeng JinDepartment of Cardiac Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China, wzhospital.cn.
Yubin XuInstitute of Hypoxia Medicine, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, 325015, Zhejiang, China, wmu.edu.cn.
Sixian WangInstitute of Hypoxia Medicine, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, 325015, Zhejiang, China, wmu.edu.cn.
Lu DingInstitute of Hypoxia Medicine, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, 325015, Zhejiang, China, wmu.edu.cn.
Yuhao ChenInstitute of Hypoxia Medicine, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, 325015, Zhejiang, China, wmu.edu.cn.
Miqi ZhouInstitute of Hypoxia Medicine, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, 325015, Zhejiang, China, wmu.edu.cn.
Xiufang ChenDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, 325015, Zhejiang, China, wmu.edu.cn.
Xiaofang FanInstitute of Hypoxia Medicine, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, 325015, Zhejiang, China, wmu.edu.cn.
Yongsheng GongInstitute of Hypoxia Medicine, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, 325015, Zhejiang, China, wmu.edu.cn.
Ming LiCardiac Regeneration Research Institute, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, 325015, Zhejiang, China, wmu.edu.cn.
Yongyu WangInstitute of Hypoxia Medicine, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, 325015, Zhejiang, China, wmu.edu.cn.ORCID https://orcid.org/0000-0002-6088-8887

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thoracic aortic dissection (TAD) is a life-threatening condition characterized by medial degeneration and vascular smooth muscle cell (VSMC) dysfunction, with no effective medical therapy currently available. The underlying pathological mechanisms of TAD remain incompletely understood. In this study, we used a nonintegrated episomal vector-based reprograming system to generate induced pluripotent stem cells (iPSCs) from TAD patients and healthy controls. Both TAD and normal iPSCs expressed key pluripotency markers and were capable of differentiating into the three germ layers in vitro. These iPSCs were differentiated into vascular smooth muscle cells (VSMCs) through a mesodermal intermediate for disease modeling. VSMCs derived from both TAD and normal iPSCs expressed smooth muscle

Indexed as

collagen IVdisease modelingiPSCsthoracic Aortic dissectionVSMCs

Identifiers

PMID41497804
PMCPMC12767432

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.