Evidence map›Paper›PMID 41498025›Full record

ArticleMediators of inflammation2025

lncRNA NKILA Promotes Warburg Effect and Immune Escape in Intrahepatic Cholangiocarcinoma by Regulating the MTX1/TOMM40 Axis.

Meiying Zhu, Hui Zhu, Zunqiang Zhou, Haiming Zheng, Zhixia Dong, Wenhong Dong, Xinjian Wan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Meiying ZhuDigestive Endoscopic Center, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China, sjtu.edu.cn.ORCID https://orcid.org/0009-0007-7251-0818
Hui ZhuInstitute of Diagnostic and Interventional Radiology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China, sjtu.edu.cn.
Zunqiang ZhouDepartment of Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China, sjtu.edu.cn.ORCID https://orcid.org/0000-0002-5052-6428
Haiming ZhengDigestive Endoscopic Center, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China, sjtu.edu.cn.
Zhixia DongDigestive Endoscopic Center, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China, sjtu.edu.cn.
Wenhong DongDigestive Endoscopic Center, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China, sjtu.edu.cn.
Xinjian WanDigestive Endoscopic Center, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China, sjtu.edu.cn.ORCID https://orcid.org/0000-0002-4201-633X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aims: Intrahepatic cholangiocarcinoma (ICC) is an aggressive malignancy with high heterogeneity and poor prognosis. Long noncoding RNAs (lncRNAs) play critical roles in tumorigenesis through dysregulated expression. We explored the effects and mechanisms of nuclear transcription factor NF-κB interacting lncRNA (NKILA) in ICC. Methods: Bioinformatic analysis was performed to determine the expression and relationship of NKILA with metaxin 1 (MTX1), and translocase of outer mitochondrial membrane 40 (TOMM40) expression in ICC tissue samples. Cholangiocarcinoma cell lines were cultured in vitro and the transplanted tumor model was constructed in vivo to study the role of NKILA in ICC. Immunohistochemistry (IHC), Western blot, and quantitative real-time polymerase chain reaction (qRT-PCR) were used to detect the effects of NKILA on the Warburg effect, autophagy, programed cell death 1 ligand 1 (PD-L1) expression, and CD8 Results: We found that NKILA, MTX1, and TOMM40 were substantially upregulated in ICC tissues, and NKILA silencing reduced MTX1-TOMM40 binding in ICC cells. NKILA facilitated proliferation, invasion, Warburg effects, and autophagy of ICC cells by regulating mammalian target of rapamycin (mTOR) pathway, PD-L1 expression, and CD8 Conclusions: LncRNA NKILA promotes Warburg effect and immune escape in ICC by regulating the MTX1/TOMM40 axis.

Indexed as

Bile Duct NeoplasmsCholangiocarcinomaMitochondrial Membrane Transport ProteinsRNA, Long NoncodingWarburg Effect, OncologicAnimalsAutophagyCell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticHumansMaleMiceMice, NudeMitochondrial Precursor Protein Import Complex Proteinslong noncoding RNA NKILA, humanMitochondrial Membrane Transport ProteinsMitochondrial Precursor Protein Import Complex ProteinsRNA, Long Noncodingglycolytic reprogrammingimmune escapeintrahepatic cholangiocarcinomametaxin 1/translocase of outer mitochondrial membrane 40nuclear transcription factor NF-κB interacting lncRNA

Identifiers

PMID41498025
PMCPMC12767443

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.