ReviewMediators of inflammation2025
Interplay Between Key Molecular Signaling Pathways and Immune Players Following Brain Irradiation.
Review in Mediators of inflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Potential neuroprotective and therapeutic agents and their mechanisms for irradiation-induced brain injury.Ibrain · 2026Review
- Interplay Between Key Molecular Signaling Pathways and Immune Players Following Brain Irradiation.Mediators of inflammation · 2025Review
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Irradiation (IRT) has been used extensively for the diagnosis and treatment of primary as well as metastatic brain tumors. Although the susceptibility of the radiation-induced brain injury or damage (RIBI) is partially associated with the sensitivity of particular cell types, pathways of injury in other types of brain disease or damage implicate the significance of the interaction between cell compartments. IRT-induced double-strand breaks (DSBs) are the utmost detrimental kind of DNA damage, which result in cell death as well as sustainable chromosomal reconfigurations following IRT exposure to the brain. It is worth noting that IRT-induced DSBs, and stimulation of interplay of key signaling pathways such as mitogen-activated protein kinases (MAPK), JAK/STAT, phosphoinositide-3-kinase/protein kinase B/AKT (PI3K-PKB/AKT), protein 53 (p53), mammalian target of rapamycin (mTOR), NF-kB, transforming growth factor beta (TGF-
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.