Evidence map›Paper›PMID 41498178›Full record

ReviewAdvanced materials (Deerfield Beach, Fla.)2026

Sculpting the Future of Bone: The Evolution of Absorbable Materials in Orthopedics.

Zhao Wang, Zehui Lv, Xuejie Cai, Yingjie Wang, Bo Peng, Haojing Xu, Hualuo Pang, Xingdong Yang, Jiawei Xu, Yixin Bian and 4 more

Abstract readReview
In one paragraph

Review in Advanced materials (Deerfield Beach, Fla.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Zhao WangDepartment of Orthopedic Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Zehui LvDepartment of Orthopedic Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Xuejie CaiDepartment of Orthopedic Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Yingjie WangDepartment of Orthopedic Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Bo PengState Key Laboratory of Clean and Efficient Turbomachinery Power Equipment, Department of Mechanical Engineering, Tsinghua University, Beijing, China.
Haojing XuState Key Laboratory of Clean and Efficient Turbomachinery Power Equipment, Department of Mechanical Engineering, Tsinghua University, Beijing, China.
Hualuo PangState Key Laboratory of Clean and Efficient Turbomachinery Power Equipment, Department of Mechanical Engineering, Tsinghua University, Beijing, China.
Xingdong YangDepartment of Orthopedic Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Jiawei XuDepartment of Orthopedic Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Yixin BianDepartment of Orthopedic Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Bin FengDepartment of Orthopedic Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Peng WenState Key Laboratory of Clean and Efficient Turbomachinery Power Equipment, Department of Mechanical Engineering, Tsinghua University, Beijing, China.
Yufeng ZhengSchool of Materials Science and Engineering, Peking University, Beijing, China.
Xisheng WengDepartment of Orthopedic Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.ORCID https://orcid.org/0000-0002-6021-1462

Funding

Beijing Natural Science Foundation 7232129Key-Area Research and Development Program of Guangdong Province 2023B1111050003National Natural Science Foundation of China 52471262National Natural Science Foundation of China 82572715
6 · The paper itself

Abstract

The repair of bone defects remains a major clinical challenge, as autologous grafts are constrained by donor limitations and bioinert implants often necessitate secondary surgeries. Absorbable materials, including polymers, ceramics, and metals, are rapidly transforming orthopedic care by offering temporary support and synchronized degradation to match tissue regeneration. This review highlights cutting-edge advances in composite scaffolds that enhance mechanical integrity, degradation kinetics, and osteoinductivity. We further explore innovative systems integrating stimuli-responsive smart materials (e.g., photothermal, piezoelectric), 4D printing smart materials, regenerative therapies, and bone organoids. Emerging clinical data are discussed in the context of diseases such as osteonecrosis, osteomyelitis, and osteoporosis. Looking forward, we outline transformative directions, including AI-driven scaffold design, gradient architectures, and immunomodulatory strategies to resolve the spatiotemporal mismatch between degradation and regeneration. This review offers a forward-looking framework for next-generation multifunctional, bioresponsive orthopedic implants.

Indexed as

Absorbable ImplantsBiocompatible MaterialsBone and BonesOrthopedicsAnimalsBone RegenerationHumansTissue EngineeringTissue ScaffoldsBiocompatible Materialsabsorbable materialsbone regenerationcomposite scaffoldsorthopedic implantssmart materials

Identifiers

PMID41498178
PMCPMC12902643

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.