Evidence map›Paper›PMID 41498544›Full record

ReviewJournal of virology2026

Viruses and the host replisome: discovering oncogenic mechanisms of small DNA tumor viruses.

Christopher D Collins, Matthew Stefely, Kavi Prem Milan Mehta, Megan E Spurgeon

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Christopher D CollinsJohn W. and Jeanne M. Rowe Center for Research in Virology, Madison, Wisconsin, USA.ORCID 0000-0001-9653-8590
Matthew StefelyMorgridge Institute for Research, Madison, Wisconsin, USA.ORCID 0009-0009-0438-3700
Kavi Prem Milan MehtaDepartment of Comparative Biosciences, University of Wisconsin-Madison School of Veterinary Medicine, Madison, Wisconsin, USA.ORCID 0000-0002-2582-073X
Megan E SpurgeonJohn W. and Jeanne M. Rowe Center for Research in Virology, Madison, Wisconsin, USA.ORCID 0000-0002-9753-6615

Funding

NCI NIH HHS L70 CA294320
6 · The paper itself

Abstract

Human papillomavirus (HPV) and Merkel cell polyomavirus (MCPyV) are DNA tumor viruses that cause human cancer. The mechanisms by which HPV and MCPyV oncoproteins induce genomic instability are not well defined. This minireview discusses the influence of these oncoproteins on the repertoire of proteins at replicating DNA, known as the host replisome, and discusses how new technologies like isolation of proteins on nascent DNA (iPOND) can drive the discovery of viral dysregulation of the host replisome to enhance our understanding of viral oncogenesis.

Indexed as

DNA ReplicationDNA Tumor VirusesHost-Pathogen InteractionsHuman Papillomavirus VirusesMerkel cell polyomavirusCarcinogenesisDNA DamageDNA, ViralGenomic InstabilityHumansOncogene Proteins, ViralPapillomaviridaeReplisomesTumor Virus InfectionsVirus ReplicationDNA, ViralOncogene Proteins, ViralReplisomesDNA damageDNA damage repairDNA replicationDNA tumor viruseshost replisomehuman papillomavirusiPONDMerkel cell polyomavirusviral oncoproteins

Identifiers

PMID41498544
PMCPMC12911864

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.