ArticleCell reports2026
Chimeric brain models to study human glial-neuronal and macroglial-microglial interactions.
Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Human Stem Cell-Derived Models of the Alzheimer's Disease Neuroimmune System.International journal of molecular sciences · 2026Review
- Perisynaptic Astrocytic Processes as Communication Hubs and Early Sites of Dysfunction.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2026Review
- From insights to innovations: evaluating preclinical paradigms in demyelinating disease therapeutics.Lab animal · 2026Review
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9 authors.
Funding
Abstract
Chimeric brain models generated by transplanting human pluripotent stem cell (hPSC)-derived neural cells are valuable for studying the development and function of human neural cells in vivo. To explore glial-neuronal and glial-glial interactions, we co-engraft hPSC-derived primitive neural progenitor cells and primitive macrophage progenitors into neonatal mouse brains, generating chimeric brains containing human microglia, macroglia, and neurons. Using super-resolution imaging and 3D reconstruction, we observe human microglia pruning synapses and engulfing neurons. Single-cell RNA sequencing reveals human glial progenitor populations and dynamic stages of astroglial development resembling those in the human brain. Cell-cell communication analysis identifies strong human neural interactions, including NRXN-NLGN3 signaling between neurons and astrocytes and SPP1- and PTN-MK-mediated communication between microglia and astroglia. This co-transplantation model provides a powerful approach to study complex human glial-neuronal interactions and mechanisms underlying neurological diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.