ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026
Silent yet impaired: Hidden memory processing deficits in asymptomatic individuals with moderate-to-severe white matter hyperintensities.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Impaired white matter functional networks topology changed with white matter hyperintensities burden and relationship to cognition.Brain imaging and behavior · 2026Article
- Silent yet impaired: Hidden memory processing deficits in asymptomatic individuals with moderate-to-severe white matter hyperintensities.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
introductionWhite matter hyperintensities (WMHs) are strongly associated with cognitive decline and dementia, but whether asymptomatic individuals with moderate-to-severe WMHs (msWMHs) are truly cognitively intact, particularly in visual short-term memory (VSTM), remains unclear.
methodsElectroencephalography and diffusion tensor imaging (DTI) was obtained from 45 msWMH patients and 38 normal controls during an occluded-face delay-matching task.
resultsIndividuals with msWMH showed systematic deficits in face-memory processing across encoding, maintenance, and retrieval, accompanied by reduced theta power and synchronization, altered alpha power, and disrupted theta-gamma coupling. DTI further revealed microstructural damage, particularly in the inferior fronto-occipital fasciculus (IFOF), superior longitudinal fasciculus (SLF), and inferior longitudinal fasciculus (ILF), which mediated the effects on global cognition via encoding-related theta oscillations. DISCUSSION: These findings indicate that individuals with msWMH already show hidden VSTM deficits. Theta oscillations mediate the link between tract integrity and global cognition, highlighting a potential preclinical intervention target. HIGHLIGHTS: Asymptomatic individuals with moderate-to-severe white matter hyperintensities (msWMHs) already show visual short-term memory (VSTM) deficits. Electroencephalography revealed abnormal neural oscillations during encoding, maintenance, and retrieval stages. Damage to the inferior fronto-occipital fasciculus (IFOF), superior longitudinal fasciculus (SLF), and inferior longitudinal fasciculus (ILF) affects cognition via theta oscillations. Theta activity mediates structure - function coupling and may serve as a preclinical intervention target.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.