Observational studyAlzheimer's & dementia : the journal of the Alzheimer's Association2026
Preserved muscle function as a protective factor against cognitive decline: Longitudinal results from the FINGER study.
Observational study in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Protein Consumption and Cognitive Health in Aging: Associations with Sarcopenia and Dietary Options, a Narrative Review.Nutrients · 2026Review
- Dietary Choline and Betaine Intake and 2-year Changes in Cognitive Function in Older Adults With Overweight or Obesity and Metabolic Syndrome: A Prospective Cohort Analysis.The American journal of clinical nutrition · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
introductionMuscular function is essential for healthy aging. This study examined the relationship between baseline muscle condition and changes in cognitive performance over 2 years.
methodsWe conducted an observational analysis of longitudinal data from the control arm of the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) randomized controlled trial (n = 583). Baseline physical performance was assessed using gait speed, grip strength, and Short Physical Performance Battery (SPPB). Logistic regression models analyzed associations between baseline physical performance and changes in standardized cognitive scores after 2 years.
resultsMean age was 68.6 years. Higher baseline chair stand performance, SPPB scores, and grip strength were significantly associated with more favorable 2-year trajectories in global cognition, memory, and executive function (p < 0.05), particularly for memory. Gait speed showed no significant associations.
conclusionBetter initial physical condition is linked to more favorable cognitive evolution, independent of other factors. This highlights the connection between physical and cognitive health, supporting comprehensive preventive strategies for older adults. HIGHLIGHTS: Stronger muscles are linked to slower cognitive decline before it begins. Better performance of muscular function protects against cognitive impairment in aging. Intervening muscle health impacts brain health in aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.