Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
17 authors.
Amar SinghSchulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-4721-1513
Adam HermanMinnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0001-7463-9462
Devanjan DeySchulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA.
Samuel MengeSchulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0009-0000-2641-1957
Shilpi SinghDepartment of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-9938-7043
Anna TranSchulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA.
Anders MatsonSchulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0001-8470-5822
Ahmed MouradSchulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0009-0000-6685-5659
Parthasarathy RangarajanSchulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0009-0003-5955-397X
Ravi MasuriaSchulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA.
Naoya SatoSchulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0003-4572-7855
Sarah VadnaisSchulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0009-0005-8111-3000
Joseph Sushil RaoSchulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-0197-6107
Gatikrushna SinghDepartment of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-9870-5556
Melanie L GrahamPreclinical Research Center, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-2475-6975
Sabarinathan RamachandranSchulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0003-2239-8083
Bernhard J HeringSchulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-5962-7284
Funding
University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UM1TR004405 · NCATS · UNIVERSITY OF MINNESOTA · PI Bruce R Blazar, Damien A Fair · 2023 to 2026
$30.8M
CTSA Postdoctoral T32 at University of MinnesotaT32TR004376 · NCATS · UNIVERSITY OF MINNESOTA · PI Jayne Allyn Fulkerson · 2024 to 2026
$1.1M
Deep Immune Profiling of Nonchimeric Tolerance of Transplants in Nonhuman PrimatesR21AI166163 · NIAID · UNIVERSITY OF MINNESOTA · PI HERING, BERNHARD JOSEF, RAMACHANDRAN, SABARINATHAN · 2022 to 2023
$426k
The role of the spleen in maintaining immune tolerance to transplanted isletsR21AI190721 · NIAID · UNIVERSITY OF MINNESOTA · PI SINGH, AMAR · 2025 to 2025
Inducing stable tolerance to transplants remains a challenge in immunology. Previously, we induced tolerance to allogeneic islets in nonhuman primates by preemptive alloantigen delivery to antigen-presenting cells in situ. Here, mass cytometry phenotyping with incorporated donor-derived MHC-I peptide-loaded MHC-II tetramers revealed accumulation of allospecific CD4
Indexed as
ErbB ReceptorsSignal TransductionSpleenT-Lymphocytes, RegulatoryTransplantation ToleranceAnimalsCD4-Positive T-LymphocytesNuclear Receptor Subfamily 4, Group A, Member 1T-Cell ExhaustionUp-RegulationErbB ReceptorsNuclear Receptor Subfamily 4, Group A, Member 1
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Allospecific splenic Tr1 cells drive effector T cell exhaustion through up-regulated Areg-EGFR signaling to promote transplant tolerance. · full record | Socratic