Trial reportScience translational medicine2026
Clinical testing of drug treatment shortening in patients with TB using PET/CT imaging of lung lesions.
Abstract readRandomized Controlled TrialEquivalence Trial
In one paragraph
Trial report in Science translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
55 authors.
Stephanus T MalherbeDST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Immunology, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.ORCID 0000-0002-7563-8231
Ray Y ChenTuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-6344-1442
Xiang YuTuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.ORCID 0009-0002-5365-9143
Bronwyn SmithDST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Immunology, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.ORCID 0009-0004-5272-3822
Xin LiuHenan Provincial Chest Hospital, Zhengzhou, Henan, China.
Jingcai GaoSino-US Tuberculosis Collaborative Research Program, Zhengzhou, Henan, China.
Andreas H DiaconTASK, Cape Town, South Africa.ORCID 0000-0001-8641-6792
Rodney DawsonDivision of Pulmonology, Department of Medicine, University of Cape Town Lung Institute, Centre for TB Research Innovation, Observatory 7923, Republic of South Africa.
Michele TamerisSouth African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, Department of Pathology, University of Cape Town, Observatory 7923, Republic of South Africa.ORCID 0000-0002-7983-7203
Hong ZhuSino-US Tuberculosis Collaborative Research Program, Zhengzhou, Henan, China.
Yahong QuKaifeng City Institute of Tuberculosis Prevention and Control, Kaifeng, Henan, China.
Hongjian JinXinmi Center for Disease Control and Prevention, Xinmi, Henan, China.
Shouguo PanZhongmu County Health and Epidemic Prevention Station, Zhongmu, Henan, China.
Lori E DoddClinical Trials Research and Statistics Branch, Office of Biostatistics Research, Division of Clinical Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-3433-5429
Jing WangClinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Lisa C GoldfederTuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-5507-1776
Ying CaiTuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-9145-2333
Kriti AroraTuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-4373-0367
Joel VincentTuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.ORCID 0009-0000-1692-146X
Kim NarunskyUniversity of Cape Town Lung Institute (Pty) Ltd., Mowbray, Cape Town 7700, Republic of South Africa.
Keboile SeroleCentre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory 7925, Republic of South Africa.
Rene T GoliathCentre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory 7925, Republic of South Africa.ORCID 0000-0001-9818-4634
Laylah Da CostaCentre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory 7925, Republic of South Africa.
Arshad TaliepCentre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory 7925, Republic of South Africa.ORCID 0000-0002-1385-1643
Saalikha AzizCentre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory 7925, Republic of South Africa.
Remy DaroowalaCentre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory 7925, Republic of South Africa.
Friedrich ThienemannCentre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory 7925, Republic of South Africa.ORCID 0000-0002-4801-2030
Sandra MukasaCentre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory 7925, Republic of South Africa.
Richard CourtCentre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory 7925, Republic of South Africa.ORCID 0000-0002-7927-6506
Bianca SossenCentre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory 7925, Republic of South Africa.ORCID 0000-0002-6028-3351
Petri AhlersDST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Immunology, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.ORCID 0000-0002-4493-8274
Simon C MendelsohnSouth African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, Department of Pathology, University of Cape Town, Observatory 7923, Republic of South Africa.ORCID 0000-0002-4054-2766
Lisa WhiteUniversity of Cape Town Lung Institute (Pty) Ltd., Mowbray, Cape Town 7700, Republic of South Africa.ORCID 0009-0008-9473-780X
Aurélie GouelClinical Trials Research and Statistics Branch, Office of Biostatistics Research, Division of Clinical Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.
Chuen-Yen LauHIV Dynamics and Replication Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-4337-8885
Samy HassanDepartment of Internal Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Lili LiangHenan Provincial Chest Hospital, Zhengzhou, Henan, China.
Hongfei DuanBeijing Chest Hospital, Beijing, China.
Gita K MoghaddamDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.ORCID 0000-0003-2099-8026
Praveen ParipatiOffice of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA.ORCID 0000-0001-8024-4782
Saher LahouarOffice of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA.ORCID 0009-0008-6667-6317
Michael HarrisOffice of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA.ORCID 0000-0001-8789-0912
Kurt WollenbergOffice of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA.ORCID 0000-0002-4973-9370
Brendan JeffreyOffice of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA.ORCID 0009-0006-6658-9040
Mike TartakovskyOffice of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA.ORCID 0000-0002-8132-9013
Alex RosenthalOffice of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA.ORCID 0000-0003-4190-9045
Michael DuvenhageResearch Data and Communication Technologies Inc., Garrett Park, MD, USA.ORCID 0009-0007-1300-2039
Derek T ArmstrongDepartment of Pathology, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0001-6223-4839
Taeksun SongCentre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory 7925, Republic of South Africa.ORCID 0000-0003-4478-4161
Jill WinterCatalysis Foundation for Health, San Ramon, CA, USA.ORCID 0000-0003-1345-3546
Qian GaoSchool of Basic Medical Science, Shanghai Medical College, Fudan University, Shanghai, China.ORCID 0000-0002-8489-3672
Laura E ViaTuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-6074-9521
Robert J WilkinsonCentre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory 7925, Republic of South Africa.ORCID 0000-0002-2753-1800
Gerhard WalzlDST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Immunology, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.ORCID 0000-0003-2487-125X
Clifton E BarryTuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-2927-270X
Funding
Medical Research Council CC2112Wellcome Trust 203135
Abstract
Six months of drug treatment is standard of care for drug-sensitive pulmonary tuberculosis (TB). Understanding the factors determining the length of treatment required for durable cure would allow individualization of treatment durations. We conducted a prospective, randomized, controlled noninferiority trial (PredictTB) of 4 versus 6 months of chemotherapy in patients with pulmonary TB in South Africa and China. Seven hundred and four participants with newly diagnosed, drug-sensitive TB were enrolled and stratified on the basis of radiographic disease characteristics assessed by FDG PET/CT imaging. Participants with less extensive disease (
Indexed as
Antitubercular AgentsLungPositron Emission Tomography Computed TomographyTuberculosis, PulmonaryAdultFemaleHumansMaleMiddle AgedProspective StudiesTreatment OutcomeAntitubercular Agents
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.