Evidence map›Paper›PMID 41499635›Full record

ArticlePLoS pathogens2026

cGAS-STING dependent type I IFN reduces Leptospira interrogans renal colonization in mice.

Suman Gupta, James Matsunaga, Bridget Ratitong, Andrew Manion, Sana Ismaeel, Diogo G Valadares, A Phillip West, Nagaraj Kerur, Christian Stehlik, Andrea Dorfleutner and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PLoS pathogens, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Suman GuptaDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.
James MatsunagaResearch Service, VA Greater Los Angeles Healthcare System, Los Angeles, California, United States of America.
Bridget RatitongDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.
Andrew ManionInterdisciplinary Program in Quantitative Biosciences, University of California, Santa Barbara, Santa Barbara, California, United States of America.
Sana IsmaeelDepartment of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.
Diogo G ValadaresDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.
A Phillip WestThe Jackson Laboratory, Bar Harbor, Maine, United States of America.
Nagaraj KerurDepartment of Ophthalmology and Visual Sciences, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America.
Christian StehlikDepartment of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.
Andrea DorfleutnerDepartment of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.
Jargalsaikhan DagvadorjDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.
Jenifer CoburnDepartment of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America.
Andrea J WolfDepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.
Meghan A MorrisseyMolecular Cellular and Developmental Biology Department, University of California, Santa Barbara, California, United States of America.
Suzanne L CasselDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.
David A HaakeDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, United States of America.
Fayyaz S SutterwalaDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.ORCID https://orcid.org/0000-0002-7338-3095

Funding

Virulence and Adaptation to the Host Environment of Pathogenic LeptospiraP01AI168148 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DAVID A HAAKE · 2023 to 2026
$11.8M
Innate NLRC4 signaling controls adaptive immune responsesR01AI177233 · NIAID · CEDARS-SINAI MEDICAL CENTER · PI Suzanne Cassel, Fayyaz S. Sutterwala · 2023 to 2026
$2.5M
Signal Integration during PhagocytosisR35GM146935 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI Meghan A Morrissey · 2022 to 2026
$1.9M
Regulation of cellular functions and innate immunity by interleukin-1alphaR01AI175101 · NIAID · CEDARS-SINAI MEDICAL CENTER · PI Jargalsaikhan Dagvadorj, Fayyaz S. Sutterwala · 2024 to 2026
$1.8M
NIAID NIH HHS P01 AI168148NIAID NIH HHS R01 AI175101NIAID NIH HHS R01 AI177233NIGMS NIH HHS R35 GM146935
6 · The paper itself

Abstract

Leptospira interrogans is the major causative agent of leptospirosis. Humans, canines and agricultural animals are susceptible to Leptospira species and can develop fulminant disease. Rodents serve as reservoir hosts in which the bacteria colonize the renal tubules and are excreted in the urine. The host immune response to Leptospira spp. remains poorly defined. We show that L. interrogans induces a robust type I interferon (IFN) response in human and murine macrophages that is dependent on the cytosolic dsDNA sensor Cyclic GMP-AMP Synthase (cGAS) and the Stimulator of IFN Genes (STING) signaling pathway. Further, we show that mice deficient in the IFNα/β receptor subunit 1 (IFNAR1) or STING had higher bacterial burdens and increased renal colonization following infection in vivo suggesting that cGAS-STING-driven type I IFN is required for the host defense against L. interrogans. These findings demonstrate the significance of cGAS-STING- dependent type I IFN signaling in mammalian innate immune responses to L. interrogans.

Indexed as

Interferon Type IKidneyLeptospira interrogansLeptospirosisMembrane ProteinsNucleotidyltransferasesAnimalscGAS-STING Signaling PathwayCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseHumansImmunity, InnateMacrophagesMiceMice, Inbred C57BLMice, KnockoutReceptor, Interferon alpha-betacGAS protein, mouseCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseInterferon Type IMembrane ProteinsNucleotidyltransferasesReceptor, Interferon alpha-betaSting1 protein, mouseSTING Protein

Identifiers

PMID41499635
PMCPMC12795460

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.