Evidence mapPaperPMID 41501024Full record

ArticleNature communications2026

Longitudinal metabolome profiling from pregnancy through childhood and risk of neurodevelopmental disorders at age 10.

Tingting Wang, Jens Richardt Møllegaard Jepsen, Rebecca Vinding, Nicklas Brustad, Liang Chen, María Hernández-Lorca, Mina Ali, Julie Bøjstrup Rosenberg, Parisa Mohammadzadeh, Michael Widdowson and 6 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Tingting WangCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark. ting.wang@dbac.dk.ORCID http://orcid.org/0000-0002-9100-3447
Jens Richardt Møllegaard JepsenMental Health Centre Glostrup, Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS) & Center for Neuropsychiatric Schizophrenia Research (CNSR), University of Copenhagen, Glostrup, Denmark.
Rebecca VindingCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.
Nicklas BrustadCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-6383-8845
Liang ChenCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-2269-6849
María Hernández-LorcaCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-0923-7173
Mina AliCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.
Julie Bøjstrup RosenbergCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.
Parisa MohammadzadehCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.
Michael WiddowsonCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-9715-568X
Parvaneh EbrahimiCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-9194-2073
Morten A RasmussenCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-7431-5206
Jonathan ThorsenCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-0200-0461
Klaus BønnelykkeCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-2003-1018
Bjørn H EbdrupMental Health Centre Glostrup, Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS) & Center for Neuropsychiatric Schizophrenia Research (CNSR), University of Copenhagen, Glostrup, Denmark.ORCID http://orcid.org/0000-0002-2590-5055
Bo ChawesCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark. chawes@copsac.com.ORCID http://orcid.org/0000-0001-6846-6243

Funding

EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) 946228Lundbeckfonden (Lundbeck Foundation) R269-2017-5
6 · The paper itself

Abstract

Neurodevelopmental disorders (NDD) are characterized by impairments in brain development that affect motor and cognitive systems. Early identification of NDD risk factors is crucial for prevention. Metabolomic profiling holds promise for early detection but remains underexplored in longitudinal studies. Here, we map the longitudinal metabolomic profiles in 3212 samples covering 683 metabolites from 581 mother-child pairs at six timepoints in the Danish COPSAC

Indexed as

MetabolomeNeurodevelopmental DisordersBiomarkersChildDenmarkFemaleHumansInfantLongitudinal StudiesMaleMetabolomicsNeurodevelopmentPregnancyPrenatal Exposure Delayed EffectsQuinolinic AcidRisk FactorsBiomarkersQuinolinic Acid

Identifiers

PMID41501024
PMCPMC12877160

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.