ArticleNature communications2026
Smart hybrid microscopy for cell-friendly detection of rare events.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Smart event-triggered MINFLUX microscopy to catch and follow rare events.Nature communications · 2026Article
- Smart hybrid microscopy for cell-friendly detection of rare events.Nature communications · 2026Article
- A correlative quantitative phase contrast and fluorescence super-resolution microscope for imaging molecules in their cellular context.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Fluorescence microscopy offers unparalleled access to the spatial organization and dynamics of biological events in living samples, yet capturing rare processes over extended durations remains challenging due to trade-offs between exposure to excitation light and sample health. Here, we introduce hybrid-EDA, an event-driven acquisition (EDA) framework that combines the gentleness and contextual richness of phase-contrast with the functional specificity of fluorescence. We develop surveillance for events of interest in label-free microscopy using dynamics-informed neural networks that trigger smart fluorescence acquisitions upon detection. This allows us to dramatically reduce phototoxic damage while obtaining specific and functional information from fluorescence when beneficial. We demonstrate how hybrid-EDA enables improved imaging acquisitions of organelle contacts and mitochondrial divisions. We envision that hybrid-EDA will enable insights into a range of dynamic and rare biological processes, providing a powerful and general strategy for cell-friendly imaging.
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Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.