Evidence mapPaperPMID 41501106Full record

ArticleScientific reports2026

Integration of multi-modal monitoring for dynamic control of large-scale 3D tissue bioreactors.

Laura Chastagnier, Sarah Pragnere, Yilbert Gimenez, Celine Loubière, Lucie Essayan, Kleanthis Mazarakis, Timo Schmidberger, Eric Olmos, Simon Auguste Lambert, Christophe A Marquette and 1 more

Abstract read
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Laura Chastagnier3d.FAB, CNRS, INSA, CPE-Lyon, UMR5246, ICBMS, Université Claude Bernard Lyon 1, Villeurbanne, France.
Sarah Pragnere3d.FAB, CNRS, INSA, CPE-Lyon, UMR5246, ICBMS, Université Claude Bernard Lyon 1, Villeurbanne, France.
Yilbert Gimenez3d.FAB, CNRS, INSA, CPE-Lyon, UMR5246, ICBMS, Université Claude Bernard Lyon 1, Villeurbanne, France.
Celine LoubièreUniversité de Lorraine, CNRS, LRGP, Nancy, 54001, France.
Lucie Essayan3d.FAB, CNRS, INSA, CPE-Lyon, UMR5246, ICBMS, Université Claude Bernard Lyon 1, Villeurbanne, France.
Kleanthis MazarakisSartorius Stedim UK Ltd., Epsom, KT19 9QQ, UK.
Timo SchmidbergerSartorius Stedim Biotech GmbH, August Spindler Straße 11, 37079, Göttingen, Germany.
Eric OlmosUniv Lyon, Université Claude Bernard Lyon 1, INSA Lyon, Ecole Centrale de Lyon, CNRS, Ampère, UMR5005, Villeurbanne, 69622, France.
Simon Auguste LambertLaboratoire de Tribologie et Dynamique des Systèmes, Ecole Centrale Lyon, Écully, France.
Christophe A Marquette3d.FAB, CNRS, INSA, CPE-Lyon, UMR5246, ICBMS, Université Claude Bernard Lyon 1, Villeurbanne, France. christophe.marquette@univ-lyon1.fr.
Emma Petiot3d.FAB, CNRS, INSA, CPE-Lyon, UMR5246, ICBMS, Université Claude Bernard Lyon 1, Villeurbanne, France. emma.petiot@univ-lyon1.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The translation of tissue engineering toward clinically relevant large-scale biofabrication requires continuous and non-invasive monitoring of tissue maturation. However, few studies provide an integrated and operational demonstration of how such tracking can be effectively achieved in real bioreactor environments. Here, we propose and experimentally validate a modular analytical framework that integrates physicochemical, metabolic, morphological, and perfusion monitoring strategies designed for centimeter-scale engineered tissues cultivated under perfusion. A custom perfusion bioreactor system was developed for the cultivation of 10 cm

Indexed as

BioreactorsTissue EngineeringAnimalsFibroblastsHumansLactic AcidOxygenPerfusionSpectrum Analysis, RamanLactic AcidOxygen

Identifiers

PMID41501106
PMCPMC12783805

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.