Evidence map›Paper›PMID 41501339›Full record

ArticleScientific reports2026

Elevated serotonin receptor 2A signaling restores learning and memory in a Fragile X syndrome model.

Yuchen Du, Vanessa K Miller, Andrew J Mellies, Kendal Broadie

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yuchen DuDepartments of Biological Sciences, Vanderbilt University and Medical Center, Nashville, TN, 37235, USA.
Vanessa K MillerDepartments of Biological Sciences, Vanderbilt University and Medical Center, Nashville, TN, 37235, USA.
Andrew J MelliesDepartments of Biological Sciences, Vanderbilt University and Medical Center, Nashville, TN, 37235, USA.
Kendal BroadieDepartments of Biological Sciences, Vanderbilt University and Medical Center, Nashville, TN, 37235, USA. kendal.broadie@vanderbilt.edu.

Funding

Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey L Neul · 2020 to 2026
$10.3M
In Vivo Analyses of Kinase Signaling in Learning/Memory CircuitryR01NS131557 · NINDS · VANDERBILT UNIVERSITY · PI Kendal Broadie · 2024 to 2026
$1.2M
Glial roles in experience-dependent critical period remodelingR01NS132867 · NINDS · VANDERBILT UNIVERSITY · PI Kendal Broadie · 2024 to 2026
$1.2M
National Institute of Health R01 NS131557 and NS13287NICHD NIH HHS P50 HD103537NINDS NIH HHS R01 NS131557NINDS NIH HHS R01 NS132867
6 · The paper itself

Abstract

Serotonin (5-hydroxytryptamine, 5-HT) has central roles enabling learning and memory, particularly via serotonin receptor 2A (5-HT

Indexed as

Fragile X SyndromeLearningMemoryReceptor, Serotonin, 5-HT2ASignal TransductionAnimalsDisease Models, AnimalDrosophila melanogasterDrosophila ProteinsFragile X Messenger Ribonucleoprotein 1Maze LearningMushroom BodiesSerotoninSerotonin Plasma Membrane Transport ProteinsTryptophan HydroxylaseDrosophila ProteinsFMR1 protein, DrosophilaFragile X Messenger Ribonucleoprotein 1Receptor, Serotonin, 5-HT2ASerotoninSerotonin Plasma Membrane Transport ProteinsTryptophan Hydroxylase5-HT2A receptor5-hydroxytryptamineDrosophilaMushroom bodySerotonin reuptake transporterTryptophan hydroxylase

Identifiers

PMID41501339
PMCPMC12864886

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.