Evidence map›Paper›PMID 41501465›Full record

ArticleNature2026

Intratumoural vaccination via checkpoint degradation-coupled antigen presentation.

Yu Han, Yicong Ma, Miao Pei, Shenyi Yin, Jiahao Wang, Liyu Guo, Yike Fang, Weiming Guo, Chunjiang Deng, Su Zhao and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yu Han *Institute of Chemical Biology, Shenzhen Bay Laboratory, Shenzhen, China.
Yicong Ma *Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing, China.
Miao Pei *Institute of Chemical Biology, Shenzhen Bay Laboratory, Shenzhen, China.
Shenyi YinDepartment of Biomedical Engineering, College of Future Technology, Peking University, Beijing, China.ORCID 0000-0003-2731-5689
Jiahao WangDepartment of Biomedical Engineering, College of Future Technology, Peking University, Beijing, China.
Liyu GuoInstitute of Chemical Biology, Shenzhen Bay Laboratory, Shenzhen, China.ORCID 0000-0002-4887-7771
Yike FangInstitute of Chemical Biology, Shenzhen Bay Laboratory, Shenzhen, China.
Weiming GuoSynthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing, China.ORCID 0000-0001-9223-0820
Chunjiang DengInstitute of Chemical Biology, Shenzhen Bay Laboratory, Shenzhen, China.
Su ZhaoInstitute of Chemical Biology, Shenzhen Bay Laboratory, Shenzhen, China.
Xueyin LuInstitute of Chemical Biology, Shenzhen Bay Laboratory, Shenzhen, China.
Jianzhong Jeff XiDepartment of Biomedical Engineering, College of Future Technology, Peking University, Beijing, China. jzxi@pku.edu.cn.ORCID 0000-0003-3015-8418
Heng ZhangInstitute of Chemical Biology, Shenzhen Bay Laboratory, Shenzhen, China. zhangheng@szbl.ac.cn.ORCID 0009-0009-8907-1799
Peng R ChenInstitute of Chemical Biology, Shenzhen Bay Laboratory, Shenzhen, China. pengchen@pku.edu.cn.ORCID 0000-0002-0402-7417

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Decreased cross-presentation by antigen-presenting cells induces the scarcity of tumour-reactive T cells within the tumour bed, rendering in situ T cell rejuvenation through immunogenicity reprogramming highly desirable yet challenging

Indexed as

Antigen PresentationBreast NeoplasmsCancer VaccinesAnimalsAntigen-Presenting CellsAntigens, NeoplasmAntigens, ViralB7-H1 AntigenCD8-Positive T-LymphocytesCell Line, TumorCross-PrimingCytomegalovirusFemaleHumansMiceProteolysisAntigens, NeoplasmAntigens, ViralB7-H1 AntigenCancer Vaccines

Identifiers

PMID41501465

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.