ArticleNature2026
Mimicking opioid analgesia in cortical pain circuits.
Abstract read
In one paragraph
Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Deep Learning-Based Quantification of Spontaneous Pain Behaviours in Mice.European journal of pain (London, England) · 2026Article
- Article
- Differential modulation of aversive signaling by expectation across the cingulate cortex.bioRxiv : the preprint server for biology · 2026Article
- Toward visualized pathophenotyping: a multimodal imaging-guided conceptual framework for chronic low back pain.Frontiers in medicine · 2026Article
- Cannabinoid efficacy for pain: dose, chronicity and route.Frontiers in neuroscience · 2026Review
- Site-specific noninvasive delivery of retrograde viral vectors to the brain.Bioengineering & translational medicine · 2026Article
- Reinforcement Learning in Personalized Medicine: A Comprehensive Review of Treatment Optimization Strategies.Cureus · 2025Review
- Convergent state-control of endogenous opioid analgesia.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
- Update of
Authors and funding
31 authors.
Corinna S Oswell *Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-6137-6963
Sophie A Rogers *Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Justin G James *Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-1799-3603
Nora M McCallDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-5793-1701
Alex I HsuDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, USA.
Gregory J SalimandoDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Malaika MahmoodDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Lisa M WooldridgeDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Meghan WachiraDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Adrienne Y JoDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Raquel Adaia Sandoval OrtegaDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Jessica A WojickDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Katherine BeattieDepartment of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Sofia A FarinasDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Samar N ChehimiDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-0701-9260
Amrith RodriguesDepartment of Biobehavioral Health Sciences, School of Nursing, and Translational Medicine and Human Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Jacqueline W K WuDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Lindsay L EjohDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Blake A KimmeyDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-6559-8005
Emily LoDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Ghalia AzouzDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.
Jose J VasquezDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.ORCID 0000-0002-4922-1520
Matthew R BanghartDepartment of Neurobiology, School of Biological Sciences, University of California, San Diego, San Diego, CA, USA.ORCID 0000-0001-7248-2932
Kevin T BeierDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.ORCID 0000-0002-4934-1338
Kate Townsend CreasyDepartment of Biobehavioral Health Sciences, School of Nursing, and Translational Medicine and Human Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-1870-4586
Richard C CristDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Charu RamakrishnanCNC Program, Stanford University, Stanford, CA, USA.
Benjamin C ReinerDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-7796-587X
Karl DeisserothCNC Program, Stanford University, Stanford, CA, USA.ORCID 0000-0001-9440-3967
Eric A YttriDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, USA. eyttri@andrew.cmu.edu.ORCID 0000-0002-7214-1481
Gregory CorderDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. gcorder@upenn.edu.ORCID 0000-0003-0031-0773
Funding
T32 Translational Addiction Research Fellowship ProgramT32DA028874 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI Julie A Blendy, Anna Rose Childress · 2010 to 2026
$5.0MCircuitry dynamics underlying opioid-dependence: Integrating structural, functional, and transcriptomic mechanismsR01DA056599 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI KEVIN T BEIER, Julie A Blendy · 2022 to 2026
$3.8MHarnessing cortical neuromodulation to disrupt pain perceptionDP2GM140923 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI CORDER, GREGORY · 2020 to 2022
$2.6MMapping opioid-dependence state transitions across structural, functional, and transcriptomic topologiesR01DA054374 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI BLENDY, JULIE A, CORDER, GREGORY · 2021 to 2025
$2.4MDevelopment of opioid and ketamine probes for in vivo photopharmacology (Diversity Supplement)RF1NS126073 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BANGHART, MATTHEW R., LISTON, CONOR M · 2022 to 2024
$2.0MInvestigation of neural ensembles driving pain chronificationR01NS130044 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI KEVIN T BEIER, Gregory Corder · 2023 to 2026
$1.4MDeconstructing the network mechanisms of chronic pain and reward in the amygdalaR00DA043609 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI CORDER, GREGORY · 2019 to 2021
$744kCell-specific epigenetic and transcriptomic signatures of impulsivity and its regulation by stress in the nucleus accumbensR21DA055846 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI BANGASSER, DEBRA A, REINER, BENJAMIN CHARLES · 2023 to 2024
$469kInvestigation of nociceptive endogenous opioid dynamics in the periaqueductal grayF32DA055458 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI KIMMEY, BLAKE · 2022 to 2024
$226kImpact of fentanyl dependence on a parabrachio-amygdalar opioid circuitF31DA057795 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI WOOLDRIDGE, LISA · 2023 to 2025
$122kModulating pain through cortical endogenous opioid circuitsF32DA053099 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI MCCALL, NORA · 2021 to 2022
$107kFunctional characterization of an amygdala to accumbens nociceptive circuitF31NS125927 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI WOJICK, JESSICA ANNE · 2022 to 2024
$104kNIDA NIH HHS F31 DA057795NIDA NIH HHS F31 DA062445NIDA NIH HHS F32 DA053099NIDA NIH HHS F32 DA055458NIDA NIH HHS R00 DA043609NIDA NIH HHS R01 DA054374NIDA NIH HHS R01 DA056599NIDA NIH HHS R21 DA055846NIDA NIH HHS T32 DA028874NIGMS NIH HHS DP2 GM140923NINDS NIH HHS F31 NS125927NINDS NIH HHS F31 NS143421NINDS NIH HHS R01 NS130044NINDS NIH HHS RF1 NS126073
Abstract
The anterior cingulate cortex is a key brain region involved in the affective and motivational dimensions of pain, but how opioid analgesics modulate this cortical circuit remains unclear
Indexed as
AnalgesiaAnalgesics, OpioidGyrus CinguliMorphineNeuralgiaAnimalsChronic PainDeep LearningFemaleHumansMaleMiceMice, Inbred C57BLMotivationNeuronsPain ManagementAnalgesics, OpioidMorphineReceptors, Opioid, mu
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.