ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2026
The positive allosteric modulator GNE-9278 increases gating, conductance, and Ca
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Positive allosteric modulators (PAMs) of NMDA receptors hold promise to alleviate functional deficits associated with neuropsychiatric disorders. GNE-9278 is a synthetic PAM that binds to the obligatory GluN1 subunit of NMDA receptors, yet it displays substantial subtype-specific efficacies. To examine the underlying mechanism by which GNE-9278 potentiates NMDA receptor responses, we examined electrical activity from endogenous and recombinant NMDA receptors and measured changes in kinetics, unitary conductance, and Ca
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