ArticleBMC gastroenterology2026
Characterization of neuroendocrine cell hyperplasia in autoimmune gastritis: improving H&E-based diagnosis through systematic training.
Article in BMC gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe incidence of autoimmune gastritis (AIG) is low, and our understanding of the proliferation of neuroendocrine cells, specifically enterochromaffin-like (ECL) cells, is insufficient because of the reliance on chromogranin A (CgA) staining for diagnostic assistance. The purpose of this study was to analyze the morphological characteristics of neuroendocrine cell hyperplasia in H&E-stained sections and improve pathologists' diagnostic accuracy in its identification.
methodsA total of 73 patients with AIG were reviewed in a single center-the Department of Pathology of Chuiyangliu Hospital affiliated with Tsinghua University from June 2023 to June 2024. We characterized patients with AIG, compared the identification of ECL hyperplasia between H&E-stained sections and CgA-stained sections, and analyzed the diagnostic concordance rate of pathologists before and after training on the diagnosis of ECL hyperplasia using H&E -stained sections.
resultsAge, sex and histopathological findings, such as the degree of inflammation, atrophy, and intestinal metaplasia, were not significantly related to the type of ECL hyperplasia. Fifty-three patients (72.6%) were confirmed by CgA staining to have ECL hyperplasia, and linear and micronodular forms were the most common types. After being trained on the morphology associated with ECL hyperplasia, pathologists with different years of experience significantly improved their ability to identify neuroendocrine cells in patients with AIG.
conclusionsA better understanding of the morphological assessment of ECL hyperplasia using H&E -stained sections is necessary to improve the understanding and diagnosis of ECL hyperplasia, to avoid missed diagnoses, and to facilitate subsequent clinical monitoring and treatment.
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