ArticleBMC complementary medicine and therapies2026
Antioxidant and selective cytotoxic activity of Dipterocarpus obtusifolius flower extract against gastrointestinal cancer, with bioactive component profiling.
Article in BMC complementary medicine and therapies, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundGastrointestinal (GI) malignancies exhibit significant global variations in incidence and mortality. Late diagnosis remains a major challenge especially gastric and cholangiocarcinoma, particularly in Thailand. Novel therapeutic agents from our region's traditional medicinal plants are crucial for developing cancer treatments. Dipterocarpus obtusifolius Teijsm. ex Miq., widely used in Southeast Asian traditional medicine. This study aims to bridge this gap by evaluating the phytochemical composition, antioxidant activity, cytotoxicity, and pro-apoptotic effects of crude ethanol and ethyl acetate extracts of this flower on human gastric cancer (AGS) and cholangiocarcinoma (KKU-100) cell lines.
methodsAntioxidant activity was determined using FRAP and DPPH assays, complemented by measurements of total phenolic and flavonoid contents via Folin-Ciocalteu and aluminum chloride colorimetric assays. For anticancer effects, we assessed cytotoxicity and pro-apoptotic effects in KKU-100 and AGS cell lines, further investigating downstream apoptosis by quantifying Bax and caspase-3 mRNA expression using real-time RT-PCR. Phytochemical profiling was also conducted via GC-MS and NMR.
resultsFlowers extraction of Dipterocarpus obtusifolius Teijsm. ex Miq. showed stronger FRAP activity was seen in the ethyl acetate extract, corresponding to its higher phenolic content, while greater DPPH scavenging activity (EC
conclusionThis study provides the first in vitro evidence that the Dipterocarpus obtusifolius Teijsm. ex Miq. flower extract possesses significant antioxidant activity and potent anti-proliferative effects against both cholangiocarcinoma and gastric adenocarcinoma cell lines.
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