ArticleNutrition & metabolism2026
Sex difference of the associations of sex hormone and their related indicators with all-cause mortality.
Article in Nutrition & metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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11 authors.
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Abstract
backgroundSex hormones are critical health determinants in both sexes. Some studies have found the association between sex hormones and all-cause mortality. However, the evidence of these association is limited and there is a lack of comprehensive investigation of various sex hormones.
methodsOur study included a total of 7,294 participants from the 2013 to 2016 National Health and Nutrition Examination Survey (NHANES). The total testosterone (TT), estradiol (E2), and sex hormone-binding globulin (SHBG) levels were obtained from laboratory data, free testosterone (FT), free estradiol (FE2), free androgen index (FAI) and the ratio of TT to E2 (TT/E2) were calculated. Cox proportional hazards regression models and restricted cubic spline were used to analysis the association between various sex hormones and all-cause mortality, and stratified analyses according to age, sex, race, and history of diabetes and hypertension were performed.
resultsThe final study sample included 3,473 male and 3,821 female from the NHANES. In the multivariate-adjusted model, male participants with higher FT and higher FAI had an obvious lower incidence of all-cause mortality [FT: HR, 0.41 (95% CI, 0.36-0.79); FAI: HR, 0.34 (95% CI, 0.25-0.92)], but these associations were not significant in female. And there was a positive correlation between SHBG concentration and mortality rate in both male and female participants, but the HR in males was higher than that in females [2.45 (95% CI, 1.69-6.23) vs 1.81 (95% 1.53-3.21)].
conclusionOur study found sex differences in the association of sex hormones and their related indicators with all-cause mortality, providing new insights for future research in this field.
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