ArticleEuropean journal of medical research2026
Association between lymphocyte to high-density lipoprotein ratio and total bone mineral density in 8-19-year-old children and adolescents: a cross-sectional study.
Article in European journal of medical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe lymphocyte to high-density lipoprotein ratio (LHR), a clinically novel marker, may more accurately represent inflammatory levels and body immunity compared to single parameters. However, there is not sufficient evidence that LHR and total bone mineral density (BMD) in teenagers are related.
methodsThe data utilized in this cross-sectional study derived from the National Health and Nutrition Examination Survey (NHANES), which ran from 2011 to 2018. To calculate the LHR, the lymphocyte count was divided by the HDL level. An investigation on the relationship between LHR and BMD was conducted using a linear regression analysis. Three distinct analytical scenarios employing multivariate logistic regression were implemented to evaluate the independent association between LHR activity and BMD. A stratified regression analysis was used to further examine them. In addition, threshold analysis was used to determine the inflection point.
resultsAmong 6,068 adolescents (mean age 13.18 ± 2.73 years), a significant negative association was observed. In the fully adjusted model (controlling for demographics, socioeconomic status, lifestyle, and comorbidities), each unit increase in LHR was associated with a 0.02 g/cm
conclusionsIn US children and adolescents, a higher LHR is independently associated with lower total BMD, exhibiting an L-shaped curve with a threshold effect at 1.26. These findings suggest that LHR may serve as a useful and accessible biomarker for assessing bone health risk in the young population. Further prospective studies are needed to elucidate the causal mechanisms underlying this association.
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