Evidence mapPaperPMID 41501993Full record

ArticleAlcohol and alcoholism (Oxford, Oxfordshire)2025

The effects of marital status, partner drinking, and sex differences on the likelihood of remission from alcohol use disorder.

Christina Garasky, Alexis Duncan, Fanghong Dong, Gayathri Pandey, Jiawen Zhao, Jared Balbona, Grace Chan, Weipeng Kuang, Chella Kamarajan, Martin Plawecki and 10 more

Abstract read
In one paragraph

Article in Alcohol and alcoholism (Oxford, Oxfordshire), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Christina GaraskyDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, United States.ORCID 0000-0002-0453-5796
Alexis DuncanBrown School of Social Work, Washington University in St. Louis, St. Louis, MO 63130, United States.
Fanghong DongDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, United States.
Gayathri PandeyDepartment of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY, 11203, United States.
Jiawen ZhaoDepartment of Psychiatry, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ 08901, United States.
Jared BalbonaDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, United States.
Grace ChanDepartment of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030, United States.ORCID 0000-0002-1257-6889
Weipeng KuangDepartment of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY, 11203, United States.ORCID 0009-0008-2622-2556
Chella KamarajanDepartment of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY, 11203, United States.
Martin PlaweckiDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, United States.
Victor HesselbrockDepartment of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030, United States.
Samuel KupermanDepartment of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242  United States.
Bernice PorjeszDepartment of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY, 11203, United States.
Andrey AnokhinDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, United States.
Emma JohnsonDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, United States.
Arpana AgrawalDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, United States.
Jessica SalvatoreDepartment of Psychiatry, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ 08901, United States.ORCID 0000-0001-5504-5087
Sally KuoDepartment of Psychiatry, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ 08901, United States.
Kathleen BucholzDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, United States.
Vivia McCutcheonDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, United States.

Funding

The role of remission in the intergenerational transmission of alcohol use disorder: Course, context, and offspring outcomesR01AA030563 · WASHINGTON UNIVERSITY · 2025 to 2025
$351k
NIAAA NIH HHS R01 AA030563NIH HHS R01 AA030563NIH HHS T32 DA015025NIH HHS U10 AA00840
6 · The paper itself

Abstract

objectiveMarriage is associated with improved health and alcohol outcomes, yet prior research has often combined diverse non-marital relationships, obscuring whether benefits are unique to marriage or a result of strong interpersonal relationships. This study examines whether marriage, compared to cohabitation, exclusive dating, or being single, is associated with alcohol use disorder (AUD) remission and whether this varies by sex and partner drinking.

methodParticipants were adults from the Collaborative Study on the Genetics of Alcoholism Lifespan Study (n = 1494; 54.4% female) who met criteria for lifetime DSM-5 AUD. Multivariate logistic regression models examined the association between marital status and remission. Subsequent models tested interactions among marital status, partner drinking, and sex. Predicted remission prevalence was estimated using marginal standardization and compared across groups on an additive scale using prevalence differences (PD).

resultsMarried individuals had greater predicted prevalence of remission, particularly compared to those who were exclusively dating (PD = 9.2, P = .020). Married females whose partners were average alcohol consumers (PD = 12.20, q = .049) or abstinent (PD = 17.98, q = .017), and married males whose partners had above average alcohol consumption (PD = 25.30, q = .049) had greater predicted prevalence of remission compared to their counterparts who were in non-marital committed relationships.

conclusionThe findings suggest differences in marital status and relationship factors may indicate increased risk and challenges in sustaining remission and highlight potential caveats of marital status as a protective factor. This emphasizes the need to consider these factors in designing treatment strategies.

Indexed as

Alcohol DrinkingAlcoholismMarital StatusSex CharacteristicsSexual PartnersAdultFemaleHumansMaleMiddle AgedRemission InductionSex Factorsalcohol use disorderalcohol use disorder remissionmarital statuspartner alcohol consumptionrecoverysex differences

Identifiers

PMID41501993
PMCPMC12779479

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.