ArticleJournal of cosmetic dermatology2026
A Systemic Pathophysiological View of Sensitive Skin Revealed by Proteomics: Beyond Barrier and Inflammation.
Article in Journal of cosmetic dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Synergistic Effects of Solar Exposure and Skin Sensitivity on Skin Aging: A Clinical Study Using Multimodal Noninvasive Measurements.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2026Observational
- A Systemic Pathophysiological View of Sensitive Skin Revealed by Proteomics: Beyond Barrier and Inflammation.Journal of cosmetic dermatology · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSensitive skin (SS) is a common dermatological condition characterized by enhanced reactivity to environmental, chemical, and cosmetic stimuli, often accompanied by impaired barrier function and discomfort sensation such as burning or itching. Despite its high prevalence, the molecular mechanism underlying SS remains poorly understood.
objectivesThis study aimed to perform a comprehensive proteomics analysis to characterize molecular alterations in SS compared with nonsensitive skin (NS), thereby uncovering key pathways involved in barrier dysfunction, oxidative stress, and neuroinflammatory responses.
methodThirty subjects with SS and 30 with NS were recruited. Stratum corneum samples were collected via tape stripping and analyzed using four-dimensional data-independent acquisition (DIA) proteomics.
resultsProteomic profiling revealed distinct molecular signatures between SS and NS. SS exhibited enrichment of pathways related to cytoskeletal remodeling, cell-cell adhesion, and tight junction organization, consistent with impaired but dynamically compensatory barrier regulation. Enhanced oxidative phosphorylation and fatty acid β-oxidation indicated increased metabolic activity, while elevated glutathione-related enzyme functions reflected altered redox balance and oxidative stress. Additionally, upregulation of MAPK signaling and neurotrophin-associated pathways suggested active neuro-inflammatory crosstalk, potentially contributing to heightened cutaneous sensitivity and inflammatory susceptibility. Additional alterations were observed in other cellular processes, reflecting the complex molecular landscape of SS.
conclusionThese findings provide new insights into the molecular basis of SS, highlighting the interplay between barrier dysfunction, oxidative stress, and neuronal activation. The identified proteins and pathways may serve as potential biomarkers for SS assessment and as targets for the development of cosmetic products or therapeutic strategies aimed at restoring skin homeostasis.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.