Evidence map›Paper›PMID 41502501›Full record

ArticleGenetics research2026

Single-Cell Transcriptomics and Integrated Bioinformatic Analysis Reveal Critical Biomarkers and Immune Infiltration Characteristics in Osteoarthritis.

Tiantian Gao, Chongshan Yang, Yikang Bi, Pingzhou Zou, Ma Wan, Shenghui Lan, Yuan Song, Yafeng Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genetics research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tiantian GaoDepartment of Orthopaedics, The Eighth People's Hospital, Jiangsu University, Shanghai, 200235, China, ujs.edu.cn.
Chongshan YangDepartment of Orthopaedics, Suzhou Wujiang District Hospital of Traditional Chinese Medicine (Suzhou Wujiang District Second People's Hospital), Suzhou, 215000, Jiangsu, China.
Yikang BiDepartment of Orthopaedics, The Eighth People's Hospital, Jiangsu University, Shanghai, 200235, China, ujs.edu.cn.
Pingzhou ZouDepartment of Orthopaedics, The Eighth People's Hospital, Jiangsu University, Shanghai, 200235, China, ujs.edu.cn.
Ma WanDepartment of Orthopaedics, The Eighth People's Hospital, Jiangsu University, Shanghai, 200235, China, ujs.edu.cn.
Shenghui LanDepartment of Orthopaedics, The Eighth People's Hospital, Jiangsu University, Shanghai, 200235, China, ujs.edu.cn.
Yuan SongDepartment of Orthopaedics, The Eighth People's Hospital, Jiangsu University, Shanghai, 200235, China, ujs.edu.cn.ORCID 0009-0003-2737-9292
Yafeng XuDepartment of Orthopaedics, The Eighth People's Hospital, Jiangsu University, Shanghai, 200235, China, ujs.edu.cn.ORCID 0009-0009-8508-1420

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Osteoarthritis (OA) is a complex, progressive joint disease characterized by cartilage degradation and inflammation. Traditional bulk tissue analyses have limited our understanding of the cellular diversity within OA tissues. Methods: This study employed scRNA-seq and integrated bioinformatic analyses to investigate the cellular composition and molecular pathways involved in OA. Publicly available datasets were analyzed to identify differentially expressed genes (DEGs) and enriched pathways. The genes, such as Results: We analyzed cartilage samples from OA and normal individuals (GSE220243) and identified eight distinct chondrocyte subpopulations, with significant pathway enrichment in TNF, TGF-β, and PI3K-Akt signaling pathways. Further differential gene expression analysis of GSE114007 identified 2247 genes, including 26 key OA-associated drug targets, such as Conclusion: Our findings provide new insights into the molecular landscape of OA, offering valuable biomarkers and therapeutic targets for future OA interventions.

Indexed as

OsteoarthritisTranscriptomeBiomarkersChondrocytesComputational BiologyGene Expression ProfilingHumansMolecular Docking SimulationNuclear Receptor Subfamily 4, Group A, Member 2Signal TransductionSingle-Cell AnalysisSingle-Cell Gene Expression AnalysisBiomarkersNR4A2 protein, humanNuclear Receptor Subfamily 4, Group A, Member 2AVPR1ABMP1chondrocyte heterogeneitymolecular dockingNR4A2osteoarthritissingle-cell RNA sequencing

Identifiers

PMID41502501
PMCPMC12771611

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.