Evidence map›Paper›PMID 41502526›Full record

ReviewOncology research2025

Circulating Tumor DNA in Cervical Cancer: Clinical Utility and Medico-Legal Perspectives.

Abdulrahman K Sinno, Aisha Mustapha, Navya Nair, Simona Zaami, Lina De Paola, Valentina Billone, Eleonora Conti, Giuseppe Gullo, Pasquale Patrizio

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Oncology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Abdulrahman K SinnoDivision of Gynecologic Oncology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Aisha MustaphaDivision of Gynecologic Oncology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Navya NairDivision of Gynecologic Oncology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Simona ZaamiDepartment of Anatomical, Histological, Forensic and Orthopedic Sciences, Sapienza University of Rome, Rome, 00161, Italy.
Lina De PaolaDepartment of Anatomical, Histological, Forensic and Orthopedic Sciences, Sapienza University of Rome, Rome, 00161, Italy.
Valentina BilloneDepartment of Obstetrics and Gynecology, AOOR Villa Sofia-Cervello, University of Palermo, Palermo, 90127, Italy.
Eleonora ContiDepartment of Obstetrics and Gynecology, AOOR Villa Sofia-Cervello, University of Palermo, Palermo, 90127, Italy.
Giuseppe GulloDepartment of Obstetrics and Gynecology, AOOR Villa Sofia-Cervello, University of Palermo, Palermo, 90127, Italy.
Pasquale PatrizioDivision of Reproductive Endocrinology & Infertility, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cervical cancer related to human papillomavirus (HPV) is a leading cause of cancer-related mortality among women worldwide. Cancer cells release fragments of their DNA, known as circulating tumor DNA (ctDNA), which can be detected in bodily fluids. A PubMed search using the terms "ctHPV" or "circulating tumor DNA" and "cervical cancer", limited to the past ten years, identified 104 articles, complemented by hand-searching for literature addressing medico-legal implications. Studies were evaluated for relevance and methodological quality. Detection and characterization of circulating tumor HPV DNA (ctHPV DNA) have emerged as promising tools for assessing prognosis and disease recurrence in cervical cancer. Detection techniques include polymerase chain reaction (PCR), digital droplet PCR (ddPCR), and next-generation sequencing (NGS). This review summarizes current knowledge on ctHPV DNA in cervical cancer and explores its clinical and medico-legal implications, including management of discordant results, diagnostic errors, liability, and data protection compliance.

Indexed as

Circulating Tumor DNAPapillomavirus InfectionsUterine Cervical NeoplasmsBiomarkers, TumorDNA, ViralFemaleHuman Papillomavirus VirusesHumansPrognosisBiomarkers, TumorCirculating Tumor DNADNA, Viralcervical cancerCirculating tumor DNAcirculating tumor human papillomavirusmedico-legal implications

Identifiers

PMID41502526
PMCPMC12774539

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.