Evidence map›Paper›PMID 41502551›Full record

ArticleFood chemistry. Molecular sciences2026

Comparative transcriptome analysis reveals the coordinated regulation of the miR-34c-5p/AASS axis in chicken skeletal muscle development and intramuscular fat deposition.

Ke Zhang, Zhenzhen Gu, Shuohan Li, Xi Cheng, Yang Wang, Hongyu Wei, Zhimin Cheng, Yihao Zhi, Mohammed Kamal Challioui, Yulong Guo and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Food chemistry. Molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ke ZhangCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Zhenzhen GuCollege of Life Science and Technology, Xinjiang University, Urumqi 830047, China.
Shuohan LiCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Xi ChengCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Yang WangCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Hongyu WeiCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Zhimin ChengCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Yihao ZhiCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Mohammed Kamal ChalliouiCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Yulong GuoCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Hong LiCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Zhuanjian LiCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Yadong TianCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Xiangtao KangCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Xiaojun LiuCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Weihua TianCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skeletal muscles (SM) development and intramuscular fat (IMF) accumulation are critical determinants of meat quality and yield in chickens. While numerous myogenesis- or adipogenesis-related regulators have been identified in chickens, the coordinated regulation of both SM development and IMF accumulation remains poorly studied. MicroRNAs (miRNAs) have increasingly been implicated in myogenesis or adipogenesis by post-transcriptional regulating target gene expression; however, evidence on their coordinated regulation of both SM development and IMF accumulation in chickens is lacking. In this study, time-series transcriptomes for miRNA and mRNA expression were generated from breast muscle tissues of commercial Arbor Acres (AA) broilers across different developmental stages. Weighted gene co-expression network analysis and differential expression analysis revealed ten miRNAs as key regulators of chicken IMF deposition and SM development. Notably, miR-34c-5p simultaneously modulates the proliferation of both chicken primary myoblasts (CPMs) and chicken intramuscular preadipocytes (CIPs), and CPMs myogenic differentiation and CIPs adipogenic differentiation. Mechanistically, miR-34c-5p suppresses

Indexed as

AASSChickenIMF depositionmiR-34c-5pSkeletal muscle development

Identifiers

PMID41502551
PMCPMC12769826

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.