Evidence map›Paper›PMID 41502954›Full record

ArticlebioRxiv : the preprint server for biology2026

Fast dendritic excitations primarily mediate back-propagation in CA1 pyramidal neurons during behavior.

Byung Hun Lee, Pojeong Park, Xiang Wu, J David Wong-Campos, Junjie Xu, Marley Xiong, Yitong Qi, Yi-Chieh Huang, Daniel G Itkis, Sarah E Plutkis and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Byung Hun LeeDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Pojeong ParkDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-5574-6104
Xiang WuDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
J David Wong-CamposDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Junjie XuDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Marley XiongDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Yitong QiDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Yi-Chieh HuangDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Daniel G ItkisDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Sarah E PlutkisJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia, USA.
Luke D LavisJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia, USA.ORCID 0000-0002-0789-6343
Adam E CohenDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-8699-2404

Funding

Two-Photon All-Optical Electrophysiology in Behaving MiceRF1NS126043 · NINDS · HARVARD UNIVERSITY · PI COHEN, ADAM EZRA · 2022 to 2022
$2.2M
Chemigenetic voltage indicators for far-red and two-photon imaging in vivoRF1NS133755 · NINDS · BROWN UNIVERSITY · PI ABDELFATTAH, AHMED · 2023 to 2023
$2.2M
Brain-wide correlation of single-cell firing properties to patterns of gene expressionRF1MH117042 · NIMH · HARVARD UNIVERSITY · PI COHEN, ADAM EZRA · 2018 to 2018
$1.2M
NIMH NIH HHS RF1 MH117042NINDS NIH HHS RF1 NS126043NINDS NIH HHS RF1 NS133755
6 · The paper itself

Abstract

Dendrites integrate synaptic inputs to trigger action potentials, and dendrites carry back-propagating action potentials (bAPs) to synapses where these signals contribute to plasticity. Despite strong evidence for a rich repertoire of nonlinear dendritic excitations, the

Identifiers

PMID41502954
PMCPMC12773015

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.