Evidence map›Paper›PMID 41502956›Full record

ArticlebioRxiv : the preprint server for biology2026

SEZ6L2 Loss Disrupts Motor Coordination, Cognitive Function, and Synaptic Connectivity.

Julia M Granato, Nina Silver, Alison Hobbins, John Randolph, Angela Stout, Harris A Gelbard, Jenny M Gunnersen, Samuel J Mackenzie, Patricia M White, Jennetta W Hammond

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Julia M GranatoNeuroscience Graduate Program, University of Rochester Medical Center, Rochester, NY.ORCID 0000-0001-6596-4079
Nina SilverDepartment of Neurology, University of Rochester Medical Center, Rochester, NY.
Alison HobbinsDepartment of Neurology, University of Rochester Medical Center, Rochester, NY.
John RandolphDepartment of Neurology, University of Rochester Medical Center, Rochester, NY.
Angela StoutDepartment of Neurology, University of Rochester Medical Center, Rochester, NY.
Harris A GelbardDepartment of Neurology, University of Rochester Medical Center, Rochester, NY.
Jenny M GunnersenDepartment of Anatomy and Physiology, University of Melbourne, Melbourne, VIC 3010, Australia.
Samuel J MackenzieDepartment of Neurology, University of Rochester Medical Center, Rochester, NY.
Patricia M WhiteDepartment of Neuroscience, University of Rochester Medical Center, Rochester, NY.ORCID 0000-0001-8374-7721
Jennetta W HammondDepartment of Neurology, University of Rochester Medical Center, Rochester, NY.ORCID 0000-0002-3949-1594

Funding

University of Rochester Intellectual and Developmental Disabilities Research CenterP50HD103536 · NICHD · UNIVERSITY OF ROCHESTER · PI JOHN J FOXE, Anna K Majewska · 2020 to 2026
$9.8M
Sez6 proteins as protection factors in complement-mediated synaptic pruningR01NS121130 · NINDS · UNIVERSITY OF ROCHESTER · PI HAMMOND, JENNETTA W · 2021 to 2025
$1.9M
Graduate Training in NeuroscienceT32NS115705 · NINDS · UNIVERSITY OF ROCHESTER · PI Anna K Majewska, Nathan A Smith · 2020 to 2026
$1.3M
Role of the Sez6 family in synapse pruningR21NS111255 · NINDS · UNIVERSITY OF ROCHESTER · PI HAMMOND, JENNETTA W · 2019 to 2020
$424k
NICHD NIH HHS P50 HD103536NINDS NIH HHS R01 NS121130NINDS NIH HHS R21 NS111255NINDS NIH HHS T32 NS115705
6 · The paper itself

Abstract

The SEZ6 family, composed of SEZ6, SEZ6L, and SEZ6L2, plays essential roles in neurodevelopment, synaptic organization, and complement regulation. However, the specific contribution of SEZ6L2 to brain function remains largely unexplored. In this study, we provide the first comprehensive behavioral and neurobiological characterization of

Indexed as

behaviorcortexmotor coordinationneuronSEZ6SEZ6LSEZ6L2

Identifiers

PMID41502956
PMCPMC12773009

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.