ArticleBioactive materials2026
Dynamic modelling of liver-bone axis: A microphysiological approach to hepatic osteodystrophy.
Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Hepatic osteodystrophy (HOD) is a metabolic bone disorder associated with chronic liver disease (CLD), marked by disrupted bone remodelling, reduced mineralization, and altered osteoblast-osteoclast dynamics. Despite its clinical relevance, mechanistic understanding of the liver-bone axis remains limited due to the shortcomings of conventional in-vitro and in-vivo models in capturing inter-organ crosstalk. To address this, we developed dual-organ perfusion-based micro-physiological devices (MPDs) that integrates human-derived liver and bone tissues-like scaffolds enabling unidirectional perfusion, permitting dynamic exchange of metabolites, cytokines, and signalling factors between hepatocyte spheroids and osteogenic co-cultures under physiologically relevant and controlled dynamic flow. Hepatic fibrosis was induced using carbon tetrachloride (CCl
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