ArticleJBMR plus2026
Association of computed tomography (CT)-derived muscle area and density at multiple sites with 10-year fracture risk in older men.
Megan Hetherington-Rauth, Tyler A Mansfield, Leon Lenchik, Ashley A Weaver, Elsa S Strotmeyer, Eric S Orwoll, Peggy M Cawthon
Abstract read
In one paragraphArticle in JBMR plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
7 authors.
Tyler A MansfieldCalifornia Pacific Medical Center Research Institute, San Francisco, CA 94158, United States.
Leon LenchikDepartment of Radiology, Stanford School of Medicine, Stanford, CA 94305, United States.
Eric S OrwollDepartment of Endocrinology, Diabetes and Clinical Nutrition, Oregon Health and Science University, Portland, OR 97239, United States.
Peggy M CawthonCalifornia Pacific Medical Center Research Institute, San Francisco, CA 94158, United States.
Funding
Oregon Clinical and Translational Research Institute - The National COVID Cohort Collaborative (N3C)UL1TR002369 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Cynthia D Morris, Christopher G. Slatore · 2017 to 2026
$78.4MWake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI STEPHEN B. KRITCHEVSKY · 2002 to 2026
$36.4MLong term fracture risk and change in peripheral bone in the oldest old men: The MrOS studyR01AG066671 · NIA · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI BOUXSEIN, MARY L, CAWTHON, PEGGY MANNEN · 2020 to 2024
$13.3MCTSA UM1 Program at Wake ForestUM1TR004929 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Jamy D Ard, KRISTIE L FOLEY · 2024 to 2026
$11.9MOsteoporotic Fractures in Men (MrOS) - San Francisco Coordinating CenterU01AR066160 · NIAMS · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI CUMMINGS, STEVEN RON · 2013 to 2017
$9.3MOsteoporotic Fractures in Men (MrOS) - MinneapolisU01AG042145 · NIA · UNIVERSITY OF MINNESOTA · PI ENSRUD, KRISTINE · 2013 to 2019
$5.3MOsteporotic Fractures in Men (MrOS)- Admin CenterU01AG027810 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI ORWOLL, ERIC S. · 2006 to 2017
$5.1MOsteoporotic Fractures in Men (MrOS) - PortlandU01AG042124 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI ORWOLL, ERIC S. · 2013 to 2019
$3.0MOsteoporatic Fractures in Men (MrOS)U01AG042168 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KADO, DEBORAH · 2013 to 2017
$3.0MOsteoporotic Fractures in Men (Mr. Os) Palo AltoU01AG042143 · NIA · STANFORD UNIVERSITY · PI STEFANICK, MARCIA L. · 2013 to 2017
$3.0MOsteoporotic Fractures in Men (Mr.OS)U01AG042139 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CAULEY, JANE ANN · 2013 to 2017
$2.9MOsteoporotic Fractures in Men_MrOS Renewal_BirminghamU01AG042140 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SHIKANY, JAMES M · 2013 to 2019
$2.7MNCATS NIH HHS UL1 TR002369NCATS NIH HHS UM1 TR004929NIAMS NIH HHS U01 AR066160NIA NIH HHS P30 AG021332NIA NIH HHS R01 AG066671NIA NIH HHS R21 AG070804NIA NIH HHS U01 AG027810NIA NIH HHS U01 AG042124NIA NIH HHS U01 AG042139NIA NIH HHS U01 AG042140NIA NIH HHS U01 AG042143NIA NIH HHS U01 AG042145NIA NIH HHS U01 AG042168
6 · The paper itselfAbstract
Loss of muscle quantity and quality with age has been related to fracture risk independent of areal BMD (aBMD) assessed by DXA. Automated approaches to assess muscle on CT images make it more feasible to assess associations of muscle quantity (cross-sectional area) and quality (density) of multiple anatomical regions on fracture risk. We investigated whether automated analysis of muscle area and density at the trunk (L1 and L3) and proximal thigh (right and left) predicted 10-yr fracture risk (any clinical, clinical spine, and non-spine) independent of DXA aBMD as well as CT vBMD and muscle function in older men from the Osteoporotic Fractures in Men (MrOS) study. Men with CT imaging and complete covariate measures were included (
Indexed as
automated image analysisBMDDXAosteoporosissarcopenia
Identifiers
PMID41503149
PMCPMC12771367
What Socratic holds
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LicenceCC BY-NC
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