Evidence map›Paper›PMID 41503152›Full record

ArticleJBMR plus2026

Ultrashort echo time quantitative magnetization transfer MRI detects non-enzymatic crosslinking of collagen in ex vivo rat bones.

Soo Hyun Shin, Dina Moazamian, Kaixin Pan, Qingbo Tang, Arya Suprana, Saeed Jerban, Yajun Ma, Eric Y Chang, Sameer B Shah, Nigel A Calcutt and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JBMR plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Soo Hyun ShinDepartment of Radiology, University of California, San Diego, La Jolla, CA, 92093, United States.ORCID https://orcid.org/0000-0003-1875-2908
Dina MoazamianDepartment of Radiology, University of California, San Diego, La Jolla, CA, 92093, United States.
Kaixin PanShu Chien-Gene Lay Department of Bioengineering, University of California, San Diego, La Jolla, CA, 92093, United States.ORCID https://orcid.org/0009-0000-1429-6744
Qingbo TangDepartment of Radiology, University of California, San Diego, La Jolla, CA, 92093, United States.
Arya SupranaDepartment of Radiology, University of California, San Diego, La Jolla, CA, 92093, United States.
Saeed JerbanDepartment of Radiology, University of California, San Diego, La Jolla, CA, 92093, United States.ORCID https://orcid.org/0000-0001-6450-2892
Yajun MaDepartment of Radiology, University of California, San Diego, La Jolla, CA, 92093, United States.
Eric Y ChangDepartment of Radiology, University of California, San Diego, La Jolla, CA, 92093, United States.
Sameer B ShahShu Chien-Gene Lay Department of Bioengineering, University of California, San Diego, La Jolla, CA, 92093, United States.
Nigel A CalcuttDepartment of Pathology, University of California, San Diego, La Jolla, CA, 92093, United States.
Robert L SahShu Chien-Gene Lay Department of Bioengineering, University of California, San Diego, La Jolla, CA, 92093, United States.
Gina WoodsDepartment of Medicine, University of California, San Diego, La Jolla, CA, 92093, United States.
Jiang DuDepartment of Radiology, University of California, San Diego, La Jolla, CA, 92093, United States.

Funding

Ultrashort Echo Time Magnetic Resonance Imaging of the Lumbar Intervertebral Disc.R01AR079484 · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2025 to 2025
$615k
Knee evaluation under mechanical loading by cones ultrashort echo time MR imagingK01AR080257 · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2025 to 2025
$120k
BLRD VA I01 BX005952NIAMS NIH HHS K01 AR080257NIAMS NIH HHS R01 AR068987NIAMS NIH HHS R01 AR075825NIAMS NIH HHS R01 AR079484
6 · The paper itself

Abstract

Increased bone fragility despite preserved or elevated BMD in type 2 diabetes mellitus (T2DM) is linked to nonenzymatic collagen crosslinking via advanced glycation end-products (AGEs). However, there is no noninvasive method clinically available to probe these collagen alterations in the bone. We examined the potential of ultrashort echo time quantitative magnetization transfer (UTE-qMT) MRI for detecting AGE-induced collagen crosslinking in bones. Rat tibial bones were subject to ribosylation ex vivo to induce AGE accumulation. UTE-qMT MRI was performed to quantify the magnetization exchange rate (k

Indexed as

bonequantitative magnetization transferribosylationtype 2 diabetesUTE-MRI

Identifiers

PMID41503152
PMCPMC12771379

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.