Evidence map›Paper›PMID 41503188›Full record

ArticleKidney medicine2026

Symptom Burden and Patient-Reported Outcomes in Kidney Transplant Recipients: Results From the TransplantLines Biobank and Cohort Studies.

Niels L Riemersma, Tim J Knobbe, Daan Kremer, Svea Nolte, Ute Bültmann, Coby Annema, Naser B N Shehab, Michele F Eisenga, Stefan P Berger, Stephan J L Bakker and 44 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

54 authors.

Niels L RiemersmaUniversity of Groningen, University Medical Center Groningen, Department of Internal Medicine, Division of Nephrology, Groningen, The Netherlands.
Tim J KnobbeUniversity of Groningen, University Medical Center Groningen, Department of Internal Medicine, Division of Nephrology, Groningen, The Netherlands.
Daan KremerUniversity of Groningen, University Medical Center Groningen, Department of Internal Medicine, Division of Nephrology, Groningen, The Netherlands.
Svea NolteUniversity of Groningen, University Medical Center Groningen, Department of Internal Medicine, Division of Nephrology, Groningen, The Netherlands.
Ute BültmannUniversity of Groningen, University Medical Center Groningen, Community and Occupational Medicine, Groningen, The Netherlands.
Coby AnnemaUniversity of Groningen, University Medical Center Groningen, Department of Health Sciences, Section of Nursing Science, Groningen, The Netherlands.
Naser B N ShehabUniversity of Groningen, University Medical Center Groningen, Department of Internal Medicine, Division of Nephrology, Groningen, The Netherlands.
Michele F EisengaUniversity of Groningen, University Medical Center Groningen, Department of Internal Medicine, Division of Nephrology, Groningen, The Netherlands.
Stefan P BergerUniversity of Groningen, University Medical Center Groningen, Department of Internal Medicine, Division of Nephrology, Groningen, The Netherlands.
Stephan J L BakkerUniversity of Groningen, University Medical Center Groningen, Department of Internal Medicine, Division of Nephrology, Groningen, The Netherlands.
TransplantLines Investigators
C AnnemaUniversity Medical Center Groningen, UMC Groningen Transplant Center, Groningen, The Netherlands.
S J L BakkerUniversity Medical Center Groningen, UMC Groningen Transplant Center, Groningen, The Netherlands.
S P BergerUniversity Medical Center Groningen, UMC Groningen Transplant Center, Groningen, The Netherlands.
H BlokzijlUniversity Medical Center Groningen, UMC Groningen Transplant Center, Groningen, The Netherlands.
F A J A BodewesUniversity Medical Center Groningen, UMC Groningen Transplant Center, Groningen, The Netherlands.
M T de BoerUniversity Medical Center Groningen, UMC Groningen Transplant Center, Groningen, The Netherlands.
DammanUniversity Medical Center Groningen, UMC Groningen Transplant Center, Groningen, The Netherlands.
M H de BorstUniversity Medical Center Groningen, UMC Groningen Transplant Center, Groningen, The Netherlands.
A DiepstraUniversity Medical Center Groningen, UMC Groningen Transplant Center, Groningen, The Netherlands.
G DijkstraUniversity Medical Center Groningen, UMC Groningen Transplant Center, Groningen, The Netherlands.
R M DouwesUniversity Medical Center Groningen, UMC Groningen Transplant Center, Groningen, The Netherlands.
C S E DoorenbosUniversity Medical Center Groningen, UMC Groningen Transplant Center, Groningen, The Netherlands.
M F EisengaUniversity Medical Center Groningen, UMC Groningen Transplant Center, Groningen, The Netherlands.
M E ErasmusUniversity Medical Center Groningen, UMC Groningen Transplant Center, Groningen, The Netherlands.
C T GanUniversity Medical Center Groningen, UMC Groningen Transplant Center, Groningen, The Netherlands.
A W Gomes NetoUniversity Medical Center Groningen, UMC Groningen Transplant Center, Groningen, The Netherlands.
A M PosthumusUniversity Medical Center Groningen, UMC Groningen Transplant Center, Groningen, The Netherlands.
E HakUniversity Medical Center Groningen, UMC Groningen Transplant Center, Groningen, The Netherlands.
B G HepkemaUniversity Medical Center Groningen, UMC Groningen Transplant Center, Groningen, The Netherlands.
J JonkerUniversity Medical Center Groningen, UMC Groningen Transplant Center, Groningen, The Netherlands.
F KlontUniversity Medical Center Groningen, UMC Groningen Transplant Center, Groningen, The Netherlands.
T J KnobbeUniversity Medical Center Groningen, UMC Groningen Transplant Center, Groningen, The Netherlands.
D KremerUniversity Medical Center Groningen, UMC Groningen Transplant Center, Groningen, The Netherlands.
H G D LeuveninkUniversity Medical Center Groningen, UMC Groningen Transplant Center, Groningen, The Netherlands.
W S LexmondUniversity Medical Center Groningen, UMC Groningen Transplant Center, Groningen, The Netherlands.
V E de MeijerUniversity Medical Center Groningen, UMC Groningen Transplant Center, Groningen, The Netherlands.
G J Nieuwenhuis-MoekeUniversity Medical Center Groningen, UMC Groningen Transplant Center, Groningen, The Netherlands.
H G M NiestersUniversity Medical Center Groningen, UMC Groningen Transplant Center, Groningen, The Netherlands.
L J van PeltUniversity Medical Center Groningen, UMC Groningen Transplant Center, Groningen, The Netherlands.
R A PolUniversity Medical Center Groningen, UMC Groningen Transplant Center, Groningen, The Netherlands.
A V RanchorUniversity Medical Center Groningen, UMC Groningen Transplant Center, Groningen, The Netherlands.
J S F SandersUniversity Medical Center Groningen, UMC Groningen Transplant Center, Groningen, The Netherlands.
M J SiebelinkUniversity Medical Center Groningen, UMC Groningen Transplant Center, Groningen, The Netherlands.
R J H J A SlartUniversity Medical Center Groningen, UMC Groningen Transplant Center, Groningen, The Netherlands.
J C SwarteUniversity Medical Center Groningen, UMC Groningen Transplant Center, Groningen, The Netherlands.
D J TouwUniversity Medical Center Groningen, UMC Groningen Transplant Center, Groningen, The Netherlands.
M C van den HeuvelUniversity Medical Center Groningen, UMC Groningen Transplant Center, Groningen, The Netherlands.
C van Leer-ButerUniversity Medical Center Groningen, UMC Groningen Transplant Center, Groningen, The Netherlands.
M van LondenUniversity Medical Center Groningen, UMC Groningen Transplant Center, Groningen, The Netherlands.
Charlotte A Te Velde-KeyzerUniversity Medical Center Groningen, UMC Groningen Transplant Center, Groningen, The Netherlands.
E A M VerschuurenUniversity Medical Center Groningen, UMC Groningen Transplant Center, Groningen, The Netherlands.
M J VosUniversity Medical Center Groningen, UMC Groningen Transplant Center, Groningen, The Netherlands.
R K WeersmaUniversity Medical Center Groningen, UMC Groningen Transplant Center, Groningen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rationale & Objective: A multitude of symptoms may contribute to low health-related quality of life (HRQoL) in kidney transplant recipients (KTR). We aimed to identify the most occurring and distressing symptoms, to explore potential determinants of symptom burden, and to examine associations with patient-reported outcomes in KTR. Study Design: A cross-sectional retrospective patient-reported outcome measures study. Setting & Participants: Stable KTR ≥1 year after transplantation participating in the TransplantLines Biobank and Cohort Studies. Predictors: Clinical variables, including sex, age, and time after transplantation. Outcomes: Symptom occurrence/distress/burden, medication adherence, symptoms of depression/anxiety, societal participation, and HRQoL. Analytical Approach: Symptoms were evaluated using ridit analyses. A burden score was calculated to explore determinants of symptom burden and its associations with other patient-reported outcomes. Results: We included 936 KTR (38.8% female; mean ± SD age, 55.6 ± 13.0 years) at a median [IQR] of 2.0 [1.0-9.0] years after transplantation. Based on ridit scores, most occurring symptoms were tiredness [0.724], bruises [0.718], and lack of energy [0.688]; most distressful symptoms were menstrual problems [0.679], impotence [0.654], and joint pain [0.611]. Worse nutritional status ( Limitations: No causality can be established because of the cross-sectional design. Conclusions: The most occurring symptoms were tiredness, bruises, and lack of energy, and the most distressing symptoms were menstrual problems, impotence, and joint pain. The strongest determinants of symptom burden were female sex, malnutrition, cyclosporine use, and proton pump inhibitor use. The associations of symptom burden with patient-related outcomes underline the importance of addressing symptom status after transplant.

Indexed as

Health-related quality of lifekidney transplant recipientsmedication nonadherencepatient-reported outcomes symptom burdensymptoms of anxietysymptoms of depression

Identifiers

PMID41503188
PMCPMC12771093

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