Evidence map›Paper›PMID 41503473›Full record

ArticlemedRxiv : the preprint server for health sciences2025

MRGPRX2-expressing mast cells are increased in the GI tract of individuals with active inflammatory bowel disease and hereditary α-tryptasemia.

Michelle Galeas-Pena, Jonathan J Lyons, Dhana Llivichuzhca-Loja, Steve Everman, Ghina Yaghi, Katelyn White, Sangita Sutradhar, Tanya O Robinson, Anna H Owings, Neha S Dhaliwal and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Michelle Galeas-PenaDepartment of Medicine, Section of Gastroenterology. Tulane University School of Medicine. New Orleans, LA.ORCID 0000-0002-9257-3222
Jonathan J LyonsDivision of Allergy & Immunology, Department of Medicine, University of California San Diego, La Jolla, CA.
Dhana Llivichuzhca-LojaDepartments of Pediatrics, Immunobiology and Obstetrics, gynecology and reproductive sciences, Yale University School of Medicine, New Haven, CT.
Steve EvermanDivision of Digestive Diseases, Department of Medicine, University of Mississippi Medical Center, Jackson, MS.
Ghina YaghiDepartment of Medicine, Section of Gastroenterology. Tulane University School of Medicine. New Orleans, LA.
Katelyn WhiteDepartment of Medicine, Section of Gastroenterology. Tulane University School of Medicine. New Orleans, LA.
Sangita SutradharDepartment of Basic and Translational Sciences, University of Pennsylvania, School of Dental Medicine, Philadelphia, PA.
Tanya O RobinsonDivision of Digestive Diseases, Department of Medicine, University of Mississippi Medical Center, Jackson, MS.
Anna H OwingsDivision of Digestive Diseases, Department of Medicine, University of Mississippi Medical Center, Jackson, MS.
Neha S DhaliwalDivision of Digestive Diseases, Department of Medicine, University of Mississippi Medical Center, Jackson, MS.
Alexander CarlyeDivision of Digestive Diseases, Department of Medicine, University of Mississippi Medical Center, Jackson, MS.
Liza KonnikovaDepartments of Pediatrics, Immunobiology and Obstetrics, gynecology and reproductive sciences, Yale University School of Medicine, New Haven, CT.ORCID 0000-0003-4804-5497
Hydar AliDepartment of Basic and Translational Sciences, University of Pennsylvania, School of Dental Medicine, Philadelphia, PA.
Sarah C GloverDepartment of Medicine, Section of Gastroenterology. Tulane University School of Medicine. New Orleans, LA.

Funding

TPSAB1-derived tryptases promote myeloproliferation and anaphylaxisR00AI138586 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jonathan Lyons · 2024 to 2026
$2.3M
Repurposing Pharmacological Agents for Inherited Mast CellDisorders of the GutR21TR002639 · NCATS · YALE UNIVERSITY · PI GLOVER, SARAH C, HAMILTON, MATTHEW J · 2019 to 2020
$535k
Mast Cell G-protein Coupled Receptors in Immune Modulation of colitisR21AI190597 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ALI, HYDAR · 2025 to 2025
$447k
NCATS NIH HHS R21 TR002639NIAID NIH HHS R00 AI138586NIAID NIH HHS R21 AI190597
6 · The paper itself

Abstract

Hereditary α-tryptasemia (HαT), defined by increased

Indexed as

gastrointestinal tracthereditary alpha-tryptasemiainflammatory bowel diseasemass cytometryMast cellsMRGPRX2SIGLEC8

Identifiers

PMID41503473
PMCPMC12772670

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.