Evidence map›Paper›PMID 41503519›Full record

ArticleJournal of the Endocrine Society2026

Urinary Proteomics as a Noninvasive Readout of Obesity-associated Inflammation.

Esra Canki, Esther Kho, Ruud van Stiphout, Niels P Riksen, Mihai Netea, Leo A B Joosten, Rinke Stienstra, Joost Hoenderop

Abstract read
In one paragraph

Article in Journal of the Endocrine Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Esra CankiDepartment of Medical BioSciences, Radboud Institute of Medical Innovation, Radboudumc, 6525 GA Nijmegen, The Netherlands.
Esther KhoImec within OnePlanet Research Center, 6708 WE Wageningen, The Netherlands.
Ruud van StiphoutImec within OnePlanet Research Center, 6708 WE Wageningen, The Netherlands.
Niels P RiksenDepartment of Internal Medicine, Radboudumc, 6525 GA Nijmegen, The Netherlands.ORCID https://orcid.org/0000-0001-9197-8124
Mihai NeteaDepartment of Internal Medicine, Radboudumc, 6525 GA Nijmegen, The Netherlands.
Leo A B JoostenDepartment of Internal Medicine, Radboudumc, 6525 GA Nijmegen, The Netherlands.
Rinke StienstraDepartment of Internal Medicine, Radboudumc, 6525 GA Nijmegen, The Netherlands.
Joost HoenderopDepartment of Medical BioSciences, Radboud Institute of Medical Innovation, Radboudumc, 6525 GA Nijmegen, The Netherlands.ORCID https://orcid.org/0000-0002-1816-8544

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Obesity affects a large percentage of the population, and it is associated with many comorbidities. These pathologies often coincide with the presence of a low-grade chronic inflammatory state in individuals with obesity that can be measured using circulating inflammatory proteins. The objective of this study was to use a noninvasive approach to determine obesity-induced inflammation by measuring the urinary proteome of individuals with and without obesity. Methods: Morning urine samples were taken from normal-weight controls (n = 30) with a mean body mass index (BMI) of 22.8 kg/m Results: Of the 384 inflammation proteins, 48 proteins had a Conclusion: This paper shows that urine may represent a novel noninvasive approach to measure the state of inflammation in individuals with obesity using Olink targeted proteomics.

Indexed as

biomarkersBMIobesityOLINKtargeted proteomicsurine

Identifiers

PMID41503519
PMCPMC12770820

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.