Evidence map›Paper›PMID 41503551›Full record

ArticleCanadian journal of gastroenterology & hepatology2026

A Preliminary Exploratory Study on the Application of Gd-EOB-DTPA-Enhanced MRI for Assessing Gallbladder Ejection Fraction in Cholecystolithiasis Patients.

Ruikun Zhang, Boqian Chen, Xiaobing Li, Xuan Zheng, Yang Liu, Renjie Zhang, Qingteng Zeng, Hengyu Tian, Qinghua He, Shenfeng Wu and 4 more

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In one paragraph

Article in Canadian journal of gastroenterology & hepatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ruikun ZhangThe First Department of Surgery, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China, gzucm.edu.cn.
Boqian ChenIntensive Care Unit, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China, gzucm.edu.cn.
Xiaobing LiThe Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China, gzucm.edu.cn.
Xuan ZhengThe Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China, gzucm.edu.cn.
Yang LiuMedical Imaging Department, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China, gzucm.edu.cn.
Renjie ZhangThe First Department of Surgery, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China, gzucm.edu.cn.
Qingteng ZengThe First Department of Surgery, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China, gzucm.edu.cn.
Hengyu TianThe First Department of Surgery, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China, gzucm.edu.cn.
Qinghua HeThe First Department of Surgery, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China, gzucm.edu.cn.
Shenfeng WuThe First Department of Surgery, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China, gzucm.edu.cn.
Yuan GaoThe First Department of Surgery, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China, gzucm.edu.cn.
Zhujing LiMedical Imaging Department, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China, gzucm.edu.cn.
Hanqing LyuMedical Imaging Department, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China, gzucm.edu.cn.ORCID 0000-0001-7625-948X
Jialin LiuThe First Department of Surgery, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China, gzucm.edu.cn.ORCID 0009-0009-4401-7158

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To preliminarily explore the feasibility and clinical implications of using gadoxetic acid disodium (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) for assessing the gallbladder ejection fraction (GBEF) in patients with cholecystolithiasis. Methods: This retrospective analysis encompassed 81 patients with gallstones who underwent Gd-EOB-DTPA-enhanced MRI. Gallbladder volume was measured during fasting and at 1 h after a lipid-rich meal to calculate the GBEF. Two radiologists independently reviewed the images for GBEF, structural anomalies, and biliary patency. Results: The mean GBEF was 62.29% ± 25.2%. Sixty patients demonstrated a GBEF > 50%, while 21 had a GBEF ≤ 50%. The imaging also facilitated the identification of gallbladder malformations (41/81) and abnormal pancreaticobiliary junctions (20/81). Bile flow into the gallbladder via the cystic duct and into the duodenum was observed in 66 patients. Conclusion: This exploratory study suggests that Gd-EOB-DTPA-enhanced MRI is a feasible modality for simultaneous anatomical evaluation and functional assessment of the GBEF in cholecystolithiasis patients. It provides a comprehensive visualization of biliary dynamics. However, the findings are preliminary, and further validation against standard modalities with controlled study design is required to establish its accuracy and clinical utility.

Indexed as

CholecystolithiasisContrast MediaGadolinium DTPAGallbladderMagnetic Resonance ImagingAdultAgedAged, 80 and overFeasibility StudiesFemaleHumansMaleMiddle AgedRetrospective StudiesStroke VolumeContrast MediaGadolinium DTPAgadolinium ethoxybenzyl DTPAcholecystolithiasisgallbladder contractile functionGd-EOB-DTPA-enhanced MRI

Identifiers

PMID41503551
PMCPMC12771634

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.