Evidence map›Paper›PMID 41503680›Full record

SynthesisJournal of cellular and molecular medicine2026

Peripheral Blood Leukocyte Ratios as Novel Biomarkers in Brain Glioma: A Comprehensive Systematic Review and Meta-Analysis.

Fatemeh Hasani, Kimia Jazi, Kimia Vakili, Armin Tafazolimoghadam, Mehrad Namazee, Mahdi Masrour, Mohammadreza Ghanbari Boroujeni, Hossein Gandomkar, Antonio L Teixeira, Erfan Ghoodjani and 3 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of cellular and molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Fatemeh HasaniGastroenterology and Hepatology Research Center, Golestan University of Medical Sciences, Gorgan, Iran.ORCID https://orcid.org/0000-0002-9906-2521
Kimia JaziSchool of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Kimia VakiliSchool of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Armin TafazolimoghadamSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Mehrad NamazeeSchool of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Mahdi MasrourSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Mohammadreza Ghanbari BoroujeniStudents Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Hossein GandomkarDepartment of Surgical Oncology, Tehran University of Medical Medicine, Tehran, Iran.
Antonio L TeixeiraBiggs Institute, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Erfan GhoodjaniSchool of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Mohammad SamadianSkull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Fatemeh SayehmiriSkull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Seyed Ali MousavinejadSkull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory biomarkers, such as leukocyte ratios, have emerged as promising tools for diagnosing and prognosticating brain gliomas. This study systematically reviewed and analysed the diagnostic and prognostic relevance of peripheral blood leukocyte ratios in glioma. Following the PRISMA guidelines, we conducted a systematic review and meta-analysis by searching PubMed, Web of Science, and Scopus for studies published in English. Eligible studies evaluated the sensitivity, specificity, and area under the curve (AUC) of inflammatory ratios, as well as their associations with survival outcomes. Quality was assessed using the Newcastle-Ottawa Scale. A total of 29 assessments with 13,189 observations compared the neutrophil-to-lymphocyte ratio (NLR) between glioma patients and non-glioma groups, yielding a pooled standardised mean difference (SMD) of 0.445 (95% CI: 0.280-0.609, p < 0.0001; I

Indexed as

Biomarkers, TumorBrain NeoplasmsGliomaLeukocytesHumansLeukocyte CountLymphocytesNeutrophilsPrognosisBiomarkers, Tumorbiomarkersgliomaleukocyte countneutrophil‐to‐lymphocyte ratiotumour

Identifiers

PMID41503680
PMCPMC12780876

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.