ArticleSmall (Weinheim an der Bergstrasse, Germany)2026
Deciphering the Heterogeneity of Pulmonary Macrophages in Response to Fine Particles.
Article in Small (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Deciphering the Heterogeneity of Pulmonary Macrophages in Response to Fine Particles.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Readiness of theFrontiers in toxicology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
The heterogeneity of pulmonary cells affects their response to inhaled fine particles. However, the most critical responder cells in particle exposure still remain controversial, and their functional heterogeneity warrants detailed exploration. Herein, a gold nanoparticle model dual-labeled with sulfo-cyanine3 and Tag RNAs is developed, aiming to capture prominent fine particle-responsive cell subpopulations using fluorescence-activated cell sorting and single-cell RNA sequencing. Alveolar macrophages (AMs), recruited macrophages (recMacs), and interstitial macrophages (IMs) exhibited the strongest responsiveness to particles, among which 14 subsets are identified with partially overlapping yet distinct functions. Notably, AMs_3, AMs_7, and recMacs_4 subsets are highlighted in the particle-responsive single-cell atlas, as evinced from their functional scoring and Tag RNA levels. AMs_3 and AMs_7 showed function enrichment for acute-phase responses to inhaled particles, while recMacs_4 exhibited enrichment for cell chemotaxis and phagocytosis. Fine particle engulfment led to enhanced outgoing interactions between these three macrophage subsets and other cell populations within particle-responsive cellular communication networks. This study reveals that specific macrophage subpopulations act as the primary responsive cell subpopulations in engulfing inhaled particles and link their transcriptional heterogeneity to functional diversity, thereby opening a new avenue to explore the heterogeneity of immune cells in pulmonary disorders.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.